The function of Sox13 on HCC cell migration and invasion was then assessed by Transwell assay, and the results demonstrated that Sox13 promoted HCC cell invasion, migration, and epithelial-to-mesenchymal transition (EMT). Notably, the invasion, migration, and EMT of HCC cells induced by Sox13...
3C–E). The tumor growth inhibition treatment/control (T/C) ratios of IKE on tumors from SNU-668-NC cell-derived xenografts (CDX) and from SNU-668-SOX13-CDX tumors were 70.72 ± 13.81% and 31.88 ± 8.73%, respectively (Fig. 3F, left). The T/C ratios of cisplatin on...
Acts upstream of or within regulation of gamma-delta T cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; early conceptus; and genitourinary system. Orthologous to human SOX13 (SRY-box ...
Lineage-committed αβ and γδ T cells are thought to originate from common intrathymic multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node and mucosal Vγ2+γδ T cells is programmed intrathymically to produce IL-17 (Tγδ17 cells), however ...
IL-17-committed γδ T (γδT17) cells participate in many immune responses but their developmental requirements and subset specific functions remain poorly understood. Here we report that a commonly used CD45.1+ congenic C57BL/6 mouse substrain is characterized by a selective deficiency in Vγ...
Western Blot analysis of SOX13 expression in transfected 293T cell line (H00009580-T01) by SOX13 MaxPab polyclonal antibody.Lane 1: SOX13 transfected lysate(68.42 KDa).Lane 2: Non-transfected lysate. Protocol Download Application Immunofluorescence Immunofluorescence of purified MaxPab antibody to...
and Sox13 in mice Leydig cell cultures and to establish their expression profiles in postnatal mice testes at different developmental stages. Methods used include Western blots and qPCR of stimulated MA-10 cell cultures and whole mice testes. Sox9, Sox5, and Sox13 proteins were detected in MA...
Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in variousanimal lineages. At ...
In a model of psoriasis-like dermatitis, the V4(+) T17 cell subset expanded considerably in lymph nodes and homed to inflamed skin. Sox13-mutant mice were protected from psoriasis-like skin changes, which identified a role for Sox13-dependent T17 cells in this inflammatory condition.doi:...
Cytogent Cell Genet, 1996, 72 ( 2 /3 ) : 246--249.SOX20, a new member of the SOX gene family, is located on chromosome 17pl3. Meyer, J,J Wirth,M.Held,W.Schempp,G.Scherer. Cytogenetic and Genome Research . 1996Meyer J, Wirth J, Held M, et al. SOX 20, a new member of...