SOX10 is a specific pan-oligodendrocyte marker in CNS, and also highly expressed in skin melanocytes, neural crest cells and Schwann cells. Conditional ablation of Sox10 gene in mice leads to myelin defects in both the CNS and PNS [3, 4]. Conventional null mutants lack peripheral glial ...
SOX10 is a specific pan-oligodendrocyte marker in CNS, and also highly expressed in skin melanocytes, neural crest cells and Schwann cells. Conditional ablation of Sox10 gene in mice leads to myelin defects in both the CNS and PNS [3, 4]. Conventional null mutants lack peripheral glial ...
pression of PDGFRα, another marker of the oligodendrocyte lin- eage (18). Thus, SoxE transcription factors are superb candidates for regulating oligodendrocyte fate (19) but whether they work to instructively induce oligodendrocyte fate and restrict the ability of multipotential cells to produce al...
Immunocytochemistry of glial and neuronal markers in Venus (+) cells after oligodendrocyte differentiation. (a) Confocal images of the immunocytochemistry after oligodendrocyte differentiation. Venus fluorescence is shown in green, and each glial marker is shown in red. Venus (+) OPCs formed highly br...
Here, we have characterized Venus-positive cells from theSox10-Venus mouse brain for analyzing oligodendrocyte differentiation. We first purified Venus-positive cells from the postnatal day 0鈥 2 brain by flow cytometry. Most of the Venus-positive cells expressed NG2, an OPC marker. After ...
DOM; MGC15649; PCWH; SOX10; SRY (sex determining region Y)-box 10; SRY-related HMG-box gene 10; transcription factor SOX-10; WS4; WS4C; WS4mouse, human homolog of Product Datasheets Product Datasheet COA SDS Related Research Areas ...
A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development Neuron, 29 (2001), pp. 603-614 View PDFView articleView in ScopusGoogle Scholar Wegner 1999 M. Wegner From head to toes: the multiple facets of Sox proteins Nucleic Acids Res., 27 (1999), pp. 14...
Furthermore, compared with that from lenti-mCherry controls, intra-PFC injections of lenti-Sox10 increased the density of cells positive for Olig2, a transcrip- tion factor marker for the oligodendrocyte lineage (Weider et al, 2015) (Figure 3e; Student's t-test, t6 = 1.955, P = 0.049...
Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression Development, 135 (2008), pp. 637-646 CrossrefView in ScopusGoogle Scholar Florenes et al., 1994 V.A. Florenes, R. Holm, O. Myklebost, U. Lendahl...
These analyses identify the oligodendrocyte precursor marker and chromatin modifier SOX10 as a master regulator in RTK I-subtype tumours. In vitro functional studies demonstrate that SOX10 loss causes a subtype switch analogous to the proneural鈥搈esenchymal transition observed in patients at the ...