Several studies regarding the role of Sox10 in melanoma indicate that Sox10 is expressed in most if not all primary and metastatic melanoma cells and drives the expression of nestin which is correlated with poor prognosis [13,14,15]. Interestingly, Agnars- dottir and co-...
The aim of this study was to compare the SOX10 gene expression in melanoma tumors and benign melanocyte lesions as a possible biological indicator in the diagnosis and prognosis and better understanding of the molecular process involved in melanoma cancer. In this study, 25 samples of melanoma, ...
SOX10 loss sensitizes melanoma cells to cytokine-mediated inflammatory cell death. Mol Cancer Res MCR. 2024;22(2):209–20. Article PubMed CAS Google Scholar Yang K, Yun F, Shi L, Liu X, Jia YF. SOX10 promotes the malignant biological behavior of basal-like breast cancer cells by ...
SOX10 labeling was primarily used in melanoma, peripheral nerve sheath tumors, and sali- vary gland myoepitheliomas.2432-34 Recently, SOX10 was also reported to be preferentially expressed in triple-negative breast carcinomas.24 As MSCCB often showed a triple-negative phe- notype how will SOX...
Evaluation of sentinel lymph node (SLN) biopsy is considered the gold standard for the identification of early nodal metastasis and the definition of prognosis and treatment of patients with melanoma [1]. The updated European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group ...
The study also focused on the differential expression of SOX10 and the functional enrichment of associated differentially expressed genes. Furthermore, the correlation between gene expression and clinicopathological characteristics such as clinical stage, prognosis time, and tumor mutation index was assessed...
This study focused on the down-regulated expression of CMTM7 gene, and elaborated the role of CMTM7 in the development of GC, trying to show that CMTM7 has the potential of diagnosis and treatment of GC in order to better improve the survival and prognosis of patients with GC. CMTM7 ...
Immunohistochemistry (IHC) is a diagnostic technique used throughout pathology. A machine learning algorithm that could predict individual cell immunophenotype based on hematoxylin and eosin (H&E) staining would save money, time, and reduce tissue co
We herein demonstrated that the inhibition of HDAC induced the expression of HLA class I molecules through IRF1 in CCS cells, similar to melanoma. The suppression of SOX10 by small interfering RNA (siRNA) induced the expression of HLA class I molecules. In addition, the isoform-specific ...
conjunctival melanoma p16conjunctival nevus immunohistochemistryconjunctival nevus p16The role of p16 in the diagnosis and prognosis of conjunctival melanocytic lesions in the context of other clinical and immunohistochemical parameters has not been systematically explored. This study was conducted to determine ...