Carbapenem resistance inP. aeruginosacan be achieved by one or a combination of resistance mechanisms, which can include (i) chromosomal mutations that alter the OprD porin activity (reduced permeability) and promote down-regulation (e.g. mutation inmexT) or loss of the OprD porin; (ii) overex...
In addition, four types of mutation patterns were observed in the rrs gene region; S2170A, R2201G, K2202E, and a deletion in position 2207.33 rrs A1401G was further investigated to reveal the extent of capreomycin resistance in M. tuberculosis.41 It was found that 58% of isolates with ...
The living poverty variable included Basic living and Old in poverty. Basic living refers to the number of households receiving basic livelihood security. Old in poverty refers to the number of older adults living alone with basic livelihood security or low income. Both data were extracted from go...
There were two MDR isolates, one belonging to the Delhi/CAS family and the other to Uganda family. The rifampicin resistant isolates displayed three types of mutations: three isolates had a mutation at position D516V, two had S531L, while one of the isolates with D516V had a further two...
Of these mutations, three have not previously been described, E458A (GCG-GAG; GenBank: JF812083), S509R (AGC-AGA) and P535S (CCC-TCC). Five isolates (8.3%) had no mutation in the RRDR of rpoB gene. There are 55 high-level (MICX4–8 mg ml À1) and 5 low-level (MICp0.5...
All isolates but one had the PFCRT K76T mutation associated with CQ treatment failure. The results of this preliminary investigation indicate that SP may remain the treatment of choice for cases of uncomplicated malaria in south-eastern Iran.Jafari...
This may undergo mutation when bacteria develop resistance to the phages and render them not virulent (Sorek et al., 2008). In addition, a phage cocktail can increase the efficiency of phage therapy, approved as novel types of food preservatives that delay the development of drug resistance by...
Spike glycoprotein is generally regarded as conserved; however, it is not without mutation. Dominant mutation has been reported at D614G position on the SARS-CoV-2 genome [57] but not without conservation. The epitopes were predicted, and the conserved epitopes were used for the construction of...
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