Although there are no adequate and well-controlled studies in pregnant women, Sotalol HCl has been shown to cross the placenta, and is found in amniotic fluid. There has been a report of subnormal birth weight with Sotalol. Therefore, Sotalol hydrochloride should be used during pregnancy only if...
Mild side effects associated with the use of solatol include upset stomach, heartburn, loss of appetite and arm or leg pain. Patients who experience severe reactions, such as dizziness, swelling in the face or extremities, chest tightness or confusion, should call their doctor right away. Rare...
The safety and effectiveness of sotalol in children has not been established. However, the Class III electrophysiologic and beta-blocking effects, the pharmacokinetics, and the relationship between the effects (QTc interval and resting heart rate) and drug concentrations have been evaluated in children...
The efficacy and tolerability of propafenone and sotalol in the prevention of paroysmal atrial fibrillation (AF) were assessed in a doubleblind placebo-controlled study over 1 year. Participants included 300 patients (168 men and 132 women) with an average age of 52.3 years. Patients were ...
Side effects with amiodarone were more common in women, with a frequent side effect being hypothyroidism. Sotalol tolerance may have been enhanced by excluding patients with ejection fractions < 40% who have more serious cardiac disease and are potentially more prone to having adverse effects with ...
In the sotalol group, relapse to atrial fibrillation occurred in 47 of the 61 patients after an average of eight months; three experienced side effects during the titration phase. In the placebo group, 53 of the 60 patients developed atrial fibrillation after an average of four months (p<...