Betapace or Sorine: 80 mg orally every 12 hours initially; increased as needed to 120-160 mg every 12 hours (2-3 days between increments) to 160-320 mg/day divided every 8-12 hours; up to 480-640 mg/day may be required if benefits outweigh increased adverse effects Atrial Fibrillation/...
With oral doses of 160 to 640 mg/day, the surface ECG shows dose-related mean increases of 40 to 100 msec in QT and 10 to 40 msec in QTc [see Warnings and Precautions (5.1)]. No significant alteration in QRS interval is observed. In a small study (n=25) of patients with ...
Side Effects, Sotalol HClConcise Info
The stereoselectivity is important in drug designing for thebiological activityimprovement and reducesside effects. The history ofthalidomideis heartbreaking, and it shows the importance of stereochemistry indrug design. The thalidomide structure has just one chiral carbon and exists as enantiomers. Thalido...
Because of d,l-sotalol–related side effects, 17 patients (4.3%) did not undergo repeat programmed electrical stimulation. d,l-Sotalol, at a mean daily dose of 465 ± 90 mg, prevented the induction of sustained VT/VF in 151 patients (38.1%). In 119 patients (30.1%), <10 repetitive ...
In ventricular tachycardia and fibrillation, intravenous sotalol (1.5 mg/ kg), prevents reinduction by programmed electrical stimulation in 40 to 50% of cases if double stimuli are used. Both prevention of reinducible arrhythmia and the suppression of spontaneous arrhythmias on Holter recordings are ...
Historically it has been advised that some drugs that can affect the heartbeat should not be used in those with HCM, leaving people with HCM to be treated with other drugs that have undesirable side effects. We studied HCM patients who had been prescribed two of the drugs that were advised...
Significant bradycardia or hypotention, necessitating drug withdrawal, occurred in 3 of 40 (7.5%) patients in the Sotalol group. None in the Sotalol group developed Torsardes de Pointes or sustained ventricular arrhythmias or other severe side effects. The sinus heart rate increased in both groups...
Side effects with amiodarone were more common in women, with a frequent side effect being hypothyroidism. Sotalol tolerance may have been enhanced by excluding patients with ejection fractions < 40% who have more serious cardiac disease and are potentially more prone to having adverse effects with ...
The side effects of sotalol are related to its 尾- blocking activity and to its property of prolonging the QTc interval. The overall proarrhythmic effect is low but torsade de pointes may develop in conjunction with excessive lengthening of the QTc interval, bradycardia, hypokalaemia, and high...