sonogashira-hagihara偶联反应-回复 什么是偶联反应? 偶联反应(Cross-coupling reaction)是一类重要的有机合成反应,是通过两个或多个有机分子之间的键合并形成新的有机分子。这个过程发生在两个底物分子之间,一般在有机金属化合物的催化下进行。偶联反应具有高效性、高选择性和广泛适用性的特点,因此在药物合成和材料...
Castro-Stephens反应是用化学当量的铜催化,而Sonogashira反应则用催化量的钯和铜催化。 1975年,Sonogashira和Hagihara 报道了乙炔气或端基炔和芳卤或乙烯基卤在钯催化剂和铜(I)盐催化下的交叉偶联反应。他们通过使用一价铜盐作为共催化剂使反应在较温和的条件下反应,并提高了产率,而同时Cas...
Sonogashira Coupling was proposed in 1975 by Nobue Hagihara, Yasuo Tohda and Kenkichi Sonogashira. It is a cross-coupling reaction is one of the most used reaction for coupling of aryl or vinyl halides.
Copper-catalyzed Sila-SonogashiraHagihara Cross-coupling Reactionsof Alkynylsilanes with Aryl Iodides under Palladium-free Conditions Chem. Lett. 2011, 40, 972974 doi:10.1246/cl.2011.972 注:文中图片可能源于参考文献,若有侵权,请联系删除。
1975年,Sonogashira和Hagihara 报道了乙炔气或端基炔和芳卤或乙烯基卤在钯催化剂和铜(I)盐催化下的交叉偶联反应。他们通过使用一价铜盐作为共催化剂使反应在较温和的条件下反应,并提高了产率,而同时Cassar 和Heck 同时报道了此反应,但他们只使用钯催化剂,反应条件比较严苛。Sonogashira反应同时使用了钯催化剂和铜催...
用卤代芳烃或烷烃与端基炔的偶联反应。催化剂量的Pd(0)催化剂+CuI+胺的组合可以促进反应进行。 近年来,也发现在没有Pd和Cu等存在下,反应也能进行的体系。 基本文献 ・ Sonogashira, K.; Tohda, Y.; Hagihara, N.Tetrahedron lett.1975,50, 4467. doi:10.1016/S0040-4039(00)91094-3 ...
This combined material showed excellent reactivity in Suzuki-Miayura and Sonogashira-Hagihara cross-coupling reactions in water and aerial conditions. The catalyst was sufficiently thermally stable, insensitive towards oxidation and easily reusable (Scheme 41). Sign in to download hi-res image Scheme 4...
Pd and Cu co-catalyzed cross-coupling of aryl or vinyl halides (or triflate) with terminal acetylenes, known as Sonogashira-Hagihara reaction, is extensively applied for the generation of C(sp2)-C(sp) bonds under environmentally benign reaction conditions and widely employed in the total synthesis...
1975年,Sonogashira和Hagihara 报道了乙炔气或端基炔和芳卤或乙烯基卤在钯催化剂和铜(I)盐催化下的交叉偶联反应。他们通过使用一价铜盐作为共催化剂使反应在较温和的条件下反应,并提高了产率,而同时Cassar 和Heck 同时报道了此反应,但他们只使用钯催化剂,反应条件比较严苛。Sonogashira反应同时使用了钯催化剂和铜催...
Sonogashira K, Tohda Y, Hagihara N. A convenientsynthesis of acetylenes: Catalytic substitutions of acetylenic hydrogen withbromoalkenes, iodoarenes and bromopyridines. Tetrahedron Lett, 1975, 16: 4467–4470 Eckhardt M, Fu G C. The first applications ofcarbene ligands in cross-couplings of alkyl...