胰岛素样生长因子-1目的:探讨Sonic hedgehog (Shh)与人胰岛素样生长因子-1(IGF-1)介导的信号通路在促进髁突肥大病理进程中的作用及串话机制.方法:选取正常髁突及髁突肥大软骨标本,以及骨髓间充质细胞(BMSC),体外分离进行平板及三维培养,按不同的实验目的划分为不同的比较组,每个比较组按不同的实验目的各...
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Furthermore, retreatment with rShh or transfection with phShh can increase the anti-apoptosis protein Bcl-2 expression and decrease cell apoptosis. These protection effects of rShh or phShh could be abolished by cyclopamine, which is a hedgehog signaling inhibitor. Moreover, we performed co-...