Dihydroartemisinin (DHA) is a poorly water-soluble drug that displays low bioavailability after oral administration. Attempts have been made to improve the solubility of DHA. Yet, no information is available concerning improved bioavailability. This study aimed to improve the water solubility of DHA by...
The latest research indicates that HPβCD complexation with dihydroartemisinin increases dihydroartemisinin solubility and stability.20 In this work we studied the formation of an inclusion complex of ATM with HPβCD. We utilized phase-solubility techniques, molecular modeling by 1H NMR and 2D NMR spec...
Yamamoto, Formation, physical stability and in vitro antimalarial activity of dihydroartemisinin nanosuspensions obtained by co-grinding method. Drug Dev. Ind. Pharm. 34, 314–322 (2008)CrossRef 20.K. Peters, S. Leitzke, J.E. Diederichs, K. Borner, H. Hahn, R.H. Müller, S. Ehlers, ...
Artesunate remained relatively stable during storage up to 40掳C卤0.5掳C and 75% relative humidity for 3months, wherein it undergoes approximately 9% decomposition. At higher temperatures, substantially greater decomposition supervenes, with formation of dihydroartemisinin (DHA) and other products. In ...