Numerous investigators have demonstrated that solute solubility in the SCFs can be substantially improved with the addition of cosolvents (polar or non-polar)4,5,6,7,8,9,10. Gurdial et al.4, measured the solubility of o- and m-hydroxy-benzoic acid in acetone-SC-CO2and methanol-SC-CO2bina...
Dimethyl (3-oxo-1,3-dihydroisobenzofuran- 1-yl)phosphonate (12) was prepared from the reaction of 2-formyl-benzoic acid with dimethyl phosphonate and meth- anesulfonic acid in sodium methoxide at 0 °C for 6 h, with a 52% yield. The coupling of compound 10 and compound 12 afforded ...
Octadecane, benzoic acid, cyclohexane and indium standards were used to calibrate the DSC temperature scale; enthalpic response was calibrated with indium. The heat capacity signal was calibrated by comparing the response of dry, powdered aluminum oxide to the equivalent literature value in the glass ...
The present invention encompasses a process for preparing particles of secondary (2,3) alkyl sulfate surfactants with improved solubility, comprising the steps of: (a) admixing said secondary (2,3) alkyl sulfate in particulate form with a water-soluble particulate organic material to provide a ...
Chertkoff, M.J.; Martin, A.N. The solubility of Benzoic Acid in Mixed Solvents.J. Am. Pharmaceut. Assoc.1960,49, 444–447. [Google Scholar] [CrossRef] ISO/IEC Guide 98-3:2008, Uncertainty of Measurement. Part 3: Guide to the Expression of Uncertainty in Measurement, Revision 2010,...
The solubility of the investigated cocrystal slightly increased when adding small amounts of anti-solvent to the solvent, but drastically decreased for high anti-solvent amounts. Furthermore, the solubilities of nicotinamide, succinic acid and the cocrystal in the considered solvent/anti-solvent ...
Benzoic acid complexes with Eudragit E100®: New alternative antimicrobial preservatives. Int. J. Pharm. 2021, 607, 120991. [Google Scholar] [CrossRef] [PubMed] Silva, A.C.M.; Gálico, D.A.; Guerra, R.B.; Perpétuo, G.L.; Legendre, A.O.; Rinaldo, D.; Bannach, G. Thermal ...
Benzoic acid complexes with Eudragit E100®: New alternative antimicrobial preservatives. Int. J. Pharm. 2021, 607, 120991. [Google Scholar] [CrossRef] [PubMed] Silva, A.C.M.; Gálico, D.A.; Guerra, R.B.; Perpétuo, G.L.; Legendre, A.O.; Rinaldo, D.; Bannach, G. Thermal ...
1. Introduction It is established that the poor water solubility of drugs represents a critical issue for the pharmaceutical industry [1], as solubility is crucial to achieving proper bioavailability for orally administered drugs. It is assessed that 40% of the drugs currently marketed and 70–90...