PEEBLES P T, TRISCH T, PAPAGEORGE A G. Isolation of four unusual pediatric solid tumor cell lines. Pediatr Res 1978; 12: 485.Peebles PT. Trisch T, Papageorge AG: Isolation of four unusual pediatric solid tumor cell lines (abstr). Pediatr Res 12:485, 1978...
Maurer BJ, Melton L, Billups C, Cabot MC and Reynolds CP: Synergistic cytotoxicity in solid tumor cell lines between N- (4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst 92: 1897-1909, 2000.Maurer, B. J., Melton, L., Billups, C., Cabot, M. C., ...
Cancer Cell Int. 19, 112 (2019). Article PubMed PubMed Central Google Scholar Dardenne, E. et al. Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat. Struct. Mol. Biol. 19, 1139–1146 (2012). This study shows that splicing factors ...
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. Troxacitabine (Troxatyl; BCH-4556; (-)-2'-deoxy-3'-oxacytidine), a deoxycytidine analogue with an unusual dioxolane structure and nonnatural L-configura...
The pivotal challenges in the field of solid tumor CAR T cell therapy can be summarized in three major parts: recognition, trafficking, and surviving in the tumor. On the other hand, the immunosuppressive tumor microenvironment (TME) interferes with T cell activity in terms of differentiation and...
To validate its wider therapeutic potential, we next demonstrated significant cytotoxicity against ovarian cancer in anin vitroandin vivosetting and T-cell-mediated killing of a range of histologically distinct solid tumor cell lines. Overall, our ROR1 BiTE represents a promising immunotherapy approach...
In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2 A series of 200 human tumors were cultivated in vitro in an attempt to establish cell lines. Lines were established, with explant and trypsinization techniques, from 13 tumors including ...
In vitro cytotoxicity of ABT-751, a novel tubulin inhibitor, in pediatric solid tumor cell lines 4351 ABT-751 is an orally bioavailable sulfonamide that is not a substrate for P-glycoprotein and which binds the colchicine binding site of β-tubulin to inhibit tubulin polymerization. A phase I ...
We, thus, interrogated the anti-tumor reactivity of validated tumor antigen-specific TCRs revealed by NeoScreen, when autologous tumor cell lines were available (Extended Data Fig. 10b). Upon TCR cloning in primary activated T cells, all NeoScreen-derived TCRs (n = 31) specific to ...
Characterizing the complex composition of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. While patient-derived samples provide valuable insight, they are heterogeneous on multiple molecular levels, and often o