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Solid-phase synthesis is the synthesis of chemical compounds whereby the reactant molecule is chemically bound to an insoluble material and reagents are added in the solution-phase. Excess reagents can be easily removed, and purification achieved, by washing. Solid-phase methods are widely used for...
[8]Merrifield, R.B., Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide. Journal of the American Chemical Society, 1963. 85(14): p. 2149-2154. [9]Marglin, B. and R.B. Merrifield, The Synthesis of Bovine Insul...
[8]Merrifield, R.B., Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide. Journal of theAmericanChemical Society, 1963. 85(14): p. 2149-2154. [9]Marglin, B. and R.B. Merrifield, The Synthesis of Bovine Insulin by the Solid Phase Method1. Journal of theAmericanChemical ...
Summary Chapter 1 covers in detail the properties of solid-phase synthesis (SPS). A thorough listing of solid supports is given together with their main properties and their compatibility with organic reactions. Then SP linkers are described and classified on the basis of their cleavage conditions....
Solid phase synthesis 专利名称:Solid phase synthesis 发明人:Marek Kwiatkowski,Ulf Landegren,Mats Nilsson 申请号:US09423742 申请日:19991112 公开号:US06313284B1 公开日:20011106 专利内容由知识产权出版社提供 专利附图:摘要:A method of preparing an immobilized oligonucleotide having a free 3′-end ...
An efficient method for the solid-phase synthesis of N , N ′-substituted acylguanidines is presented. The key-step involves the N -acylation of resin immobilized S -methylisothiourea with a variety of carboxylic acids using PyAOP as the coupling agent. The resulting resin bound N -acyl-deri...
solid phase synthesis[2]. As a consequence, more work to adapt the most usefulorganic reactionsto solid phase synthesis is badly needed. It can be expected that much of the effort in this direction will regard chiral reactions, even if classical chiral organic synthesis will very likely ...
Combination of the conventional and solid phase approaches with retention of the best features of each is now possible. The procedure was tested by the synthesis of the crystalline tetrapeptide Z-Phe-Val-Ala-Leu-NHNH2... SS Wang,RB Merrifield - 《Journal of the American Chemical Society》 被...
This optimal situation no longer exists during the assembly of a difficult peptide, where the normally accessible solid phase Martin Quibell and Tony Johnson reaction matrix becomes partially inaccessible during assembly. This situation arises suddenly, typically 6-12 residues into the synthesis, and ...