Sodium valproate belongs to the class of drugs known as antiepileptic drugs, and it is commonly used to treat seizures, bipolar disorder, and to prevent migraines. Sodium valproate was first synthesized in the 1880s by a French chemist, but its medicinal uses were not discovered until the ...
Botulinum toxin A and valproate semisodium prevent migraineInpharma Weekly -doi:10.2165/00128413-200816300-00035NoneSpringer International PublishingInpharma Weekly
别名 [14C]-Sodium Valproate、Depakote ER、Divalproex + [13] 靶点 GABA receptor x Sodium channels 作用机制 GABA receptor激动剂(γ-氨基丁酸受体激动剂)、钠通道阻滞剂 治疗领域 神经系统疾病其他疾病 在研适应症 躁郁症偏头痛癫痫的复杂部分性发作+ [2] 非在研适应症 酒精相关疾病酗酒躁郁症1型+ [3] ...
The cocrystal of sodium valproate with valproic acid in a 1:1 stoichiometric ratio has improved stability and comparable pharmacokinetic behavior, marketed as Depakote, is the leading marketed form of valproic acid to treat epilepsy and bipolar disorder and to prevent migraine headaches (Fig. 5.44)....
Valproate should not be administered to a woman of childbearing potential unless the drug is essential to the management of her medical condition. This is especially important when valproate use is considered for a condition not usually associated with permanent injury or death (e.g., migraine). ...
Phenobarbital and valproate may increase or decrease serum phenytoin concentrations; effect of phenytoin on phenobarbital and valproate concentrations is unpredictable Monitor serum phenytoin concentrations and adjust dosage of phenytoin accordingly Dosage adjustment of some anticonvulsants may be necessary when ...
Sodium valproate and valproic acid appear to decrease barbiturate metabolism; therefore, barbiturate blood levels should be monitored and appropriate dosage adjustments made as indicated. Central nervous system depressants: The concomitant use of other central nervous system depressants, including other ...
The term valproate has been used to represent these medications. Drugs Affected By Phenytoin Table 3 includes commonly occurring drug interactions affected by phenytoin. However, this list is not intended to be inclusive or comprehensive. Individual drug package inserts should be consulted. The ...
concentration of ethosuximide, active oxcarbazepine metabolite, retigabine, rufinamide (concentration of phenytoin possibly increased), topiramate and valproate possibly reduced; concentration of eslicarbazepine, ethosuximide, lamotrigine, perampanel, tiagabine and zonisamide reduced; concentration of phenobarbital...
Valproate and vigabatrin may worsen the condition (Morrison et al., 2006; Tekgul et al., 2006). The partial control of convulsive seizures was obtained in two cases with vagal nerve stimulation (Tsao, 2010). View chapterExplore book Urea Cycle Disorders Nicholas Ah Mew, ... Andrea L. ...