Recent clinical studies assessing a new class of antidiabetic drugs, sodium-glucose cotransporter 2 inhibitors (SGLT2is) showed some unexpected beneficial results. Patients treated with SGLT2is had a significant decrease in both cardiovascular (CV) and all-cause mortality and less hospitalisations due...
Greco, A. Sodium-Glucose Cotransporter-2 Inhibitors: Elevating Standards in Cardiovascular Secondary Prevention. Am J Cardiovasc Drugs 24, 625–628 (2024). https://doi.org/10.1007/s40256-024-00666-0 Download citation Accepted03 July 2024 Published17 July 2024 Issue DateSeptember 2024 DOIhttps://...
Sodium–glucose cotransporter 2 inhibitors are a novel class of agents for the treatment of type 2 diabetes mellitus. These agents reduce hyperglycemia via a paradigm-breaking insulin-independent mechanism entailing promotion of glucosuria by inhibiting renal recovery of glucose. This ...
Sodium-glucose cotransporter-2 (SGLT2) is a protein expressed on the luminal surface of epithelial cells lining the proximal convoluted tubule of the kidneys. These transporters are responsible for absorbing roughly 90% of filtered glucose. This mechanism is efficient up to a glucose serum concentrat...
2 diabetes mellitus.#SGLT2 inhibitors were found to decrease the risk of kidney failure in patients with type 2 diabetes mellitus and also in those with CKD.#The effects of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on kidney outcomes in patients with varying combinations of heart ...
If you are one of the authors, claim this publication so you can create a plain language summary to help more people find, understand and use it. Featured Image Read the Original This page is a summary of:Sodium-glucose cotransporter 2 inhibitors and renal function钠-葡萄糖共转运体2抑制剂与...
Keywords:SGLT2 inhibitors;SGLT2i;Cardiovascular disease;Heart failure;Atherosclerotic cardiovascular disease;Diabetic kidney disease Core Tip:The new antidiabetic medication class sodium glucose cotransporter-2 inhibitors (SGLT-2i) are found to have remarkable cardiovascular (CV) benefits proven by multiple...
Joseph M Pappachan,Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PL, United Kingdom Author contributions: Mondal S contributed to the initial drafting of the work by performing the literature search and interpretation of relevant literature with help from Prama...
14 Since SGLT2 is not the only mechanism for renal glucose reabsorption, glycosuria only occurs in the presence of hyperglycemia. Thus SGLT2 inhibitors are unlikely to be of use as weight loss agents in people with normal glycemic control. In a metaanalysis in type 2 diabetes patients taking...
Sodium-glucose cotransporter 2 inhibitors, Sodium-glucose cotransporter, Diabetic nephropathy References [1] Xie Y,Bowe B,Mokdad AH,et al.Analysis of the Global Burden of Disease study highlights the global,regional,and national trends of chronic kidney disease epidemiology from 1990 to 2016[J]....