Pharmacologic class: Barbiturate Therapeutic class: Sedative-hypnotic, anticonvulsant Controlled substance schedule II Pregnancy risk category D Action Depresses sensory cortex, decreases motor activity, and alters cerebellar function; may interfere with nerve impulse transmission in brain Availability Injection:...
The effects of ethacrynate sodium on electrolytes are related to its renal pharmacologic activity and are dose dependent. The possibility of profound electrolyte and water loss may be avoided by weighing the patient throughout the treatment period, by careful adjustment of dosage, by initiating treat...
However, since both compounds yield the fluorocitrate ion in the body, where it is converted to fluoroacetate, which is responsible for the induction of pharmacologic and toxic signs (see below), it seems that this experiment is nevertheless interesting in showing a large degree of species ...
(CSF) concentrations has no definite clinical value. Nonetheless, amphotericin B assays have revealed some remarkable pharmacologic properties of ABD. When colloidal amphotericin B is admixed in serum, deoxycholate separates from amphotericin B, and more than 95% of the latter binds to serum proteins...
Withdraw prednisolone very gradually following long-term therapy with pharmacologic dosages.Adrenal suppression may persist up to 12 months in patients who receive large dosages for prolonged periods.Until recovery occurs, signs and symptoms of adrenal insufficiency may develop if subjected to stress (e...
Maximum pharmacologic activity of corticosteroids lags behind peak blood levels, suggesting that most effects of the drugs result from modification of enzyme activity rather than from direct actions by the drugs. 5.3 Pharmacokinetic properties Methylprednisolone pharmacokinetics is linear, independent of route...
( 1997 ) In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing ΔF508-CFTR . J. Clin. Invest . 100 , 2457 – 2465 .Rubenstein RC, Egan ME, Zeitlin PL (1997) In vitro pharmacologic restorati...
In contrast, pharmacologic or genetic inhibition of autophagy enhanced antitumor activity of vemurafenib, a selective and well-tolerated BRAF inhibitor, in thyroid cancer [16]. Protein degradation could occur through ubiquitin-proteasome system (UPS) or autophagy-lysosome pathway [17]. Recent studies ...
There is a tendency in current medical practice to use high (pharmacologic) doses of corticosteroids for the treatment of unresponsive shock. The following dosages of dexamethasone sodium phosphate injection have been suggested by various authors: ...
With single doses, the rate of redistribution determines duration of pharmacologic effect. Metabolism occurs in the liver through demethylation and oxidation. Side-chain oxidation is the most important biotransformation involved in termination of biologic activity. Excretion occurs via the kidneys through ...