Some extended-release products showed a significant increase in the amount of drug dissolved in the first 6 h (early burst) owing to changes in tablet surface morphology and enhanced drug dissolution. In vivo studies showed a decrease in the AUC0-t by overall average of 21.1 % using the ...
Sodium nitroprusside was infused at 3.9 mcg/kg/min for a total of 3.5 mg/kg over 15 hours prior to delivery of a 478 gram stillborn infant without any obvious anomalies. Cyanide levels in the fetal liver were less than 10 mcg/mL. Toxic levels have been reported to be more than 30 to...
Ceftriaxone for injection, USP contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity. CLINICAL PHARMACOLOGY Average plasma concentrations of ceftriaxone following a single 30-minute intravenous (IV) infusion of a 0.5, 1 or 2 g dose and intramuscular (IM) administration ...
盐酸莫西沙星氯化钠注射液(Moxifloxacin hydrochloride and sodium chloride injection) Moxifloxacin Hydrochloride and Sodium Chloride Injection (Moxifloxacin, Hydrochloride, and, Injection, Sodium, Chloride, etc) (Bai Fule) The main ingredient of this product is moxifloxacin hydrochloride. The chemical name is...
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Adverse Reactions/Side Effects The ...
Sodium bicarbonate administration in a rapid infusion or as large boluses can result in acute metabolic alkalosis, reducing serum ionized calcium. This acute shift in ionized calcium can result in tetany. The accompanying alkalosis is treatable with ammonium chloride. Hypocalcemia may be addressed with...
Table 1. Composition of different Tolmetin Fast Dissolving Tablet formulations. 2.2.2. Box-Behnken Design Evaluation In Stratigraphic Plus Soft-ware, the focused response parameters were statistically examined using a one-manner ANOVA test at the level of significance (p < 0.05) (Stat point Tech...