One of the important paradigm shifts in amyotrophic lateral sclerosis (ALS) research is the departure from the concept of “one-drug for all” to the pursuit of precision, genotype-specific pharmacological interventions [1,2]. The recognition of the fundamental heterogeneity of ALS led to the nua...
The gas phase structures of sodium cationized complexes of uracil and five thiouracils including 2-thiouracil (2SU), 5-methyl-2-thiouracil (5Me2SU), 6-methyl-2-thiouracil (6Me2SU), 4-thiouracil (4SU), and 2,4-dithiouracil (24dSU) are examined via infrared multiple photon ...
As in our previous study (Kuo et al. 2004), the F–I function provided an overall measurement of the neuronal steady-state excitability. The slope of the linear regression fitted to the ascending phase was defined as the F–I gain. The current thresholds were defined as the absolute current...