The ability of IFNg to activate the LIGHT-LT-bR pathway raised the possibility that IFNg might enhance expression levels of LIGHT and/or LT-bR. Densitometric analysis of LIGHT and LT-bR immunoblots revealed that IFNg signifi- cantly increased levels of LIGHT, but not of LT-bR, in moto...
We hypothesized that targeting oxidative stress-induced inflammation with MnP would assuage liver complications and enhance insulin sensitivity and glucose tolerance in a high-fat diet (HFD)-induced mouse model of T2D. During 12 weeks of feeding, we saw significant improvements in weight, hepatic ...