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We reasoned that hippocampal engrams, which represent ensembles of neurons with increased activity after memory formation, could underlie some contributions of the hippocampus to depression symptoms. Using the chronic social defeat stress model, we examined social defeat-related ...
In contrast, magnocellular OXT neurons that project to the central amygdala represent a fear memory engram (42). Peripherally released OXT has been shown to induce analgesia (43). Social defeat stress activates both parvocellular and magnocellular OXT neurons (17). The results of the current ...
et al. Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nat. Neurosci. 19, 564–567 (2016). Nature Communications | (2024)15:9493 13 Article https://doi.org/10.1038/s41467-024-53866-2 51. Godden, D. R. & Baddeley, A. D. Context‐dependent memory in...
Furthermore, the object place recognition test was performed to examine whether SH mice have a deficit in hippocampus-dependent memory (Squire and Zola-Morgan, 1991; Figure 1F). Again, SH mice investigated an object in a novel position significantly more than an object in a familiar position, ...
It can thus be hypothesized that D1-type receptors in the dorsal hippocampus may mediate social learning in the STFP. The objective of this study was to assess whether dorsal hippocampal administration of SCH23390 before the social interactions would block social learning in male and female mice....
They identify the ventral hippocampus in the brain as critical for storing a social memory, or engram, with connectivity to the nucleus accumbens as key to the expression of such a memory (see the figure). Authors: Kapil Saxena, Richard G. M. MorrisKapil Saxena...
Acquiring and exploiting memories of rewarding experiences is critical for survival. The spatial environment in which a rewarding stimulus is encountered regulates memory retrieval. The ventral hippocampus (vH) has been implicated in contextual memories
The hippocampus (HPC) is an extensively studied structure with a well-defined role in declarative memory, which includes memory of places, people, events, and facts1. As declarative memory consists of distinct stages, including encoding, consolidation, and recall, a key question is the extent to...