SNRNP是指小核核糖核蛋白质复合物(small nuclear ribonucleoprotein),也称作spliceosome。它是由小核RNA和蛋白质组成的复合物,在剪切作用中发挥重要作用。下面我们从以下几个方面来详细解释: 一、SNRNP的结构 SNRNP由小核RNA和一系列蛋白质组成,具有不同的亚型。不同的亚型参与不同的RNA剪切事件。小核RNA分为U1、U2...
在真核生物基因表达调控的精密机器中,剪接体(spliceosome)如同一位技艺高超的剪辑师,负责精准切除pre-mRNA中的内含子。这个巨型分子机器的核心部件——富含尿苷的小核核糖核蛋白颗粒(U-rich snRNPs),其组装过程一直是生命科学领域的重大课题。传统认知认为,七聚体Sm蛋白环(D1/D2/F/E/G/D3/B)围绕snRNA的组装必...
2024年1月9日,西湖大学施一公团队在Nature子刊Nature Structural & Molecular Biology发表了题为:Structural Insights into Branch Site Proofreading by Human Spliceosome的最新研究论文。 该研究报道了人源17S U2 snRNP复合物和剪接体pre-A...
snRNP snRNPs (pronounced "snurps"), or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential...
SnRNP, or small nuclear ribonucleoprotein, is a class of RNAs that, after assembly with specific proteins, form the core of the spliceosome. The spliceosome is responsible for removing introns from pre-messenger RNA during gene expression.
Here we identify zinc finger protein 207 (ZFP207) as a key regulator of U1 snRNP function that substantially promotes spliceosome assembly. Acute depletion of ZFP207 results in a series of molecular phenotypes indicative of U1 snRNP dysregulation. Mechanistically, the N-terminal zinc finger domains ...
[2] Zhang, X. et al. Structure of the human activated spliceosome in three conformational states. Cell Res. 28, 307–322 (2018). 来源/ 施一公团队 编辑/ 朱逸青 校对/ 张玉璇 审核/ 李凯娜
Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins...
基因别名:40K; HPRP8BP; PRP8BP; PRPF8BP; SFP38; SNRNP40; SPF38; WDR57 UniProt ID:(Human) Q96DI7 Entrez Gene ID:(Human) 9410 功能 protein bindingpoly(A) RNA binding 参与通路 RNA splicing, via transesterification reactionsmRNA splicing, via spliceosomeRNA processingRNA splicing...