目的:比较两种微阵列技术在不同时期活检及移植时机对染色体易位携带者行胚胎植入前遗传学诊断(PGD)对诊断结果及妊娠结局的影响。方法:对染色体易位携带者行PGD的152个活检周期资料进行回顾性分析,其中60个aCGH-PGD周期采用D3卵裂球活检并新鲜周期移植的策略.92个SNP—PGD周期采用滋养外胚层活检并冷冻周期移植的策略,将...
与array-CGH相比,临床应用的大多数SNP-array是包含SNP探针与拷贝数探针的杂合阵列,具有检测等位基因失衡的优势,除可检测CNV外,还可检测单亲二倍体(UPD)/杂合性缺失(loss of heterozygosity, LOH)、三倍体和> 10%比例的嵌合体,而且检测分辨率比a...
与array-CGH相比,临床应用的大多数SNP-array是包含SNP探针与拷贝数探针的杂合阵列,具有检测等位基因失衡的优势,除可检测CNV外,还可检测单亲二倍体(UPD)/杂合性缺失(loss of heterozygosity, LOH)、三倍体和> 10%比例的嵌合体,而且检测分辨率比array-CGH更高。 CMA检测的局限性在于:( 1)不能检测染色体平衡易位...
目的:比较两种微阵列技术在不同时期活检及移植时机对染色体易位携带者行胚胎植入前遗传学诊断(PGD)对诊断结果及妊娠结局的影响。方法:对染色体易位携带者行PGD的152个活检周期资料进行回顾性分析,其中60个aCGH-PGD周期采用D3卵裂球活检并新鲜周期移植的策略.92个SNP—PGD周期采用滋养外胚层活检并冷冻周期移植的策略,将...
以下对SNP array的认识,错误的是( )A.探针密度较array CGH高,分辨率高B.不可以检测三倍体C.可以检测单亲二倍体D.操作流程要求高E.无法检测线粒体疾
are also a potential source of DNA, but it is generally assumed that DNA must be extracted, or the specimen frozen, within a day or two of collection, to obtain DNA suitable for further analysis. We have assessed DNA extracted from these materials for both SNP array and array CGH. ...
Array-comparative genomic hybridisation (array-CGH) and single nucleotide polymorphism array hybridisation (SNP-array) enable genome-wide detection of copy number alterations (CNA). These techniques outperform conventional chromosomal karyotyping in relation to detection of CNAs. The discovery of previously ...
Array CGH • Cervical SCC ○ Most frequent chromosomal gains include 3q, 1q and 5p regions ○ Most frequent chromosomal losses include 14p, 13q, 2q, 4q, and 6q regions ○ Loss of heterozygosity at 3p14.2, 3p21.3, 3p24.2, 1p32.3, 1p36.21, 4q11, 4q34, 6p21.2, and 8p23.3 are det...
百度试题 题目以下哪些属于现有的PGS检测技术() A.FISHB.ArrayCGHC.SNParrayD.qPCRE.二代测序相关知识点: 试题来源: 解析 A.FISH;B.ArrayCGH;C.SNParray;D.qPCR;E.二代测序
Description : A tool to annotate CGH results and microarray data from a range of platforms, such as cDNA, expression, exon, SNP, array-CGH and ChIP-on-chip. It converts the data into standard formats that can be visualized in Affymetrix Integrated Genome Browser and GBrowse in the HapMap ...