Jafari-Oliayi等人的另一项研究还发现在原发性乳腺癌中SNHG6的表达显著上调。 此外,SNHG6沉默导致G1细胞周期阻滞,抑制细胞增殖。同时SNHG6可激活多种信号通路,包括胃癌中的MAPK和JNK通路,结肠直肠癌中的PI3K/AKT/mTOR通路和TGF-β/Smad通路。SNHG6还可以通过与p21等关键因子相互作用来调控细胞周期。 lncRNA SNH...
本研究基于前期细胞器LncRNA图谱绘制和探索,发现 LncRNASNHG6(small nucleolar RNA host gene 6) 特异性响应胆固醇,分布于溶酶体及内质网互作区域,促进肝癌的恶性增殖及不良预后。利用高通量蛋白组学技术解析了SNHG6在内质网及溶酶体定...
研究显示，SNHG6高表达与人类癌症的不良预后显著相关。多项荟萃分析表明，SNHG6表达水平与生存期呈负相关，高表达与更差的预后显著相关。综上所述，lncRNA SNHG6在癌症研究中展现出作为新型肿瘤标志物和治疗靶点的潜力。随着进一步深入研究，SNHG6在不同肿瘤中的分子机制可能存在差异，有望成为治疗新靶...
长非编码RNA SNHG6在肿瘤中的研究进展
Western blot analysis was carried out to examine the protein levels of Bax, Bcl-2, and SNHG6. Luciferase reporter and RIP assays were used to confirm the true interaction between SNHG6 and miR-135a-5p, or miR-135a-5p and ROCK. The levels of SNHG6, ROCK1 and ROCK2 were notably ...
但目前,SNHG6控调肝癌胞增殖、迁移和侵的作用机制尚不明确。生物信息学件示细袭软预测显,miR-186是 SNHG6的靶基因。研究示显,miR-186控肝癌胞调细E-cadherin表达,影响EMT的生发 [8]。miR-186靶向YAP1蛋白表达抑制Hippo信号和肝癌的生转导发[9]。基于以上的研究,本研究通肝癌患者癌及肝癌胞中过检测组织细...
摘要 目的探讨SNHG6对急性心肌梗死(AMI)小鼠左心室心肌的影响。方法将30只雄性C57/BL6小鼠构建成AMI小鼠后随机均分为AMI组、AMI+SNHG6组、AMI+miR-101-3p组、AMI+SNHG6+miR-1...展开更多 Aim To investigate the effects of the SNHG6 on the left ventricular myocardium in acute myocardial infarction(...
Long non-coding RNAs (lncRNAs), such as SNHG6, have been identified as crucial regulators in the progression of various cancers, including esophageal squamous cell carcinoma (ESCC). Although the role of SNHG6 in ESCC is not completely understood, our findings demonstrated that SNHG6 expression...
MiR-26a-5p overexpression significantly enhanced the effect of SNHG6 knockdown on the cell behaviors in BC. Furthermore, bioinformatics analysis and luciferase reporter indicated that MAPK6 was validated as a target of miR-26a-5p. Therefore, our study may reveal a novel SNHG6/miR-26a-5p/MAP...
Similar to the function of SNHG6, abnormal expression of EZH2 promotes the malignancy of EC and intensifies its resistance to 5-FU. In addition, overexpression of EZH2 abolished the role of SNHG6 silencing in 5-FU sensitivity in EC cells. SNHG6 overexpression promoted malignancy of EC and ...