此外,我们分析了SNHG14在不同级别的HCC组织中的表达,并且SNHG14在高级别(G3 / G4)的癌组织中的表达更高(图1b,P <0.001)。 为了验证SNHG14在肝癌及其附近组织中的表达,我们在66对样品中测试了SNHG14的表达,卡方分析表明SNHG14的高...
结果:SNHG14在PTC组织中的表达高于癌旁组织(P<0.05),并与淋巴结转移,病灶数有关(P均<0.05),而与年龄,性别,肿瘤大小,TNM分期无关(P均>0.05),同时,SNHG14在TPC-1细胞中的表达高于Nthy-ori3-1细胞(P<0.05).下调SNHG14后,相较于空白对照组,阴性对照组,si-SNHG14组细胞的增殖,迁移和侵袭能力均降低(...
SNHG14 miR-206-3p ABCB1 NSCLC Gefitinib 1. Introduction Lung cancer, the leading cause of cancer-related morbidity and mortality, accounts for more than a quarter in all cancer diagnosis [1]. Non-small cell lung cancer (NSCLC) is the foremost pathological sub-type and occupies approximately...
small interfering RNAs (siRNA) for SNHG14 (si-SNHG14) or si-NC, pcDNA3.1- SNHG14 overexpression vector (pc-SNHG14) or its control pcDNA vector (pc-DNA), as well as SNHG14 knockdown plasmids (SNHG14 shRNA1, SNHG14 shRNA2, and SNHG14 shRNA3) or its negative control...
Furthermore, overexpression of ATG14 could strongly recover the CRC phenotypes attenuated by shSNHG14 or miR-186 mimics. Interestingly, we constructed cisplatin-resistant CRC cells and found that overexpression of ATG14 significantly enhanced the cell proliferation rate and inhibited cell apoptosis. ...
摘要 目的探讨长链非编码RNA SNHG14(lncRNA SNHG14)靶向miR-17-5p/叉头蛋白K2(FOXK2)轴对肺炎链球菌感染的肺泡上皮细胞增殖、凋亡和炎症反应的影响。方法将肺泡上皮细胞A549分为对照组、感染...展开更多 Objective To investigate the impacts of long non-coding RNA SNHG14(lncRNA SNHG14)on proliferation...
Mechanistically, SNHG14 sponged miR-5590-3p to upregulate Zinc finger E-box binding homeobox 1 (ZEB1), and ZEB1 transcriptionally activated SNHG14 and PD-L1 to promote the immune evasion of DLBCL cells. In conclusion, we firstly showed that SNHG14/miR-5590-3p/ZEB1 positive feedback loop...
最后,进行荧光素酶报告基因分析以验证SNHG14与miR-5590-3p,miR-5590-3p和YY1之间的结合位点。结果结果表明,SNHG14在前列腺癌组织和前列腺癌细胞系中显着增加,这与前列腺癌患者的晚期和错误诊断有关。在前列腺癌组织和细胞系中,MiR-5590-3p减少,与SNHG14呈负相关。发现YY1在前列腺癌组织中增加,与miR-5590-...
死亡的ARDS患者血清lncRNA SNHG14,miR-124-3p相对表达量分别为3.07±0.42,0.91±0.17,存活的ARDS患者分别为2.60±0.37,1.11±0.17,两者比较P均<0.05.多因素Logistic回归分析结果显示,血清lncRNA SNHG14表达升高,miR-124-3p表达降低是ARDS患者死亡的独立危险因素(P均<0.05).血清lncRNA SNHG14,miR-124-3p单独...
SNHG14 expression is upregulated in CRC cells. Moreover, SNHG14 suppression inhibited the proliferation, metastasis, and epithelial-mesenchymal transition (EMT) process in CRC cells. miR-32-5p presented lower expression, which was negatively regulated by SNHG14. SKIL could combine with miR-32...