In addition, rescue experiments confirmed that upregulation of PEG10 partially restored cell function inhibition induced by SNAI3-AS1 knockdown. Therefore, we hypothesized that PEG10 may be regulated by SNAI3-AS1, which in turn mediates the malignant biological processes of HCC cells regulated by ...
如图2G所示,当SNAI1/2结合序列发生突变时,SNAI1/2过表达对荧光素酶表达的强烈抑制部分恢复,提示该序列是SNAI1/SNAI2抑制ELF3/ELF3-AS1表达所必需的。另一方面,CHIP测定表明SNAI1和SNAI2可以直接与ELF3-AS1启动子结合(图2H-J)。综上所述,SNAI2和SNAI1都参与了GC中ELF3和ELF3-AS1的转录调控。 图2 ELF3-A...
Objective: In order to explore the function and influence of long non-coding RNA SNAI3-AS1(LncRNA SNAI3-AS1,SNAI3-AS1) in the progression of osteoarthritis(OA). Methods: LncRNA SNAI3-AS1 was screened by whole-transcriptome sequencing,and its expression...
MicroRNA-seq and RNA-seq studies were conducted to reveal the biological function of ELF3-AS1 in GC. RNA pulldown and CHIRP assays were conducted to identify the protein that interacts with ELF3-AS1.A total of 123 lncRNAs were identified to be regulated by SNAI2 in GC by RNA sequencing...