1. SUBSTITUTION WITH HALIDES TO FORM ALKYL HALIDES 2. ELIMINATION OF WATER (DEHYDRATION TO ALKENES) 3. ACID/BASE REACTIONS WITH STRONG BASES/ACIDS 4. OXIDATION TO ALDEHYDES, KETONES, OR CARBOXYLIC ACIDS. Alcohols have several polar atoms, several sites of reactivity. ...
SN1 Reactions: SN1 reactions are commonly used in the synthesis of tertiary alkyl halides, where a stable carbocation can form. For example, SN1 mechanisms are involved in the formation of alcohols from alkyl halides. The use of SN1 reactions is also widespread in pharmaceuticals, where specifi...
bridged compoundssubstitution reactionsCertain S N1 reactive alkyl halides undergo C C bond formation in Lewis acid induced α-alkylations of carbonyl compounds with formal retention of configurationdoi:10.1016/S0040-4039(01)90247-3M.T. Reetz
“big barrier” to the SN1 reaction as beingcarbocation stability, That is, any factor which leads to the increased stability of a carbocation intermediate will increase the rate of the SN1. That’s why this pathway tends to be favored by tertiary alkyl halides, since the order of ...
For instance, if a tertiary alkyl halide and reacts with a nucleophile result in the formation of tertiary alcohol and halide ion. From the reaction, we can decipher that SN1 reaction is a two-step process and it leads to the formation of carbocation intermediates. The First Step: ...
mechanism. Be able to explain what makes sulfonates such great leaving groups. Be able to thoroughly describe the role of the solvent in a substitution reaction and how it interacts with the reactants, transitions states, intermediates, and products. Be able to explain how the polarity or the...