In smooth muscle (Prosser, 1974; Hurwitz and Suria, 1971; Somlyo and Somlyo, 1968), as in other types of muscle (Fuchs, 1974; Langer, 1968; Sandow, 1965), calcium is considered to be the agent that activates the contractile apparatus. Consequently, the cellular structures and reactions ...
Cyclic Nucleotides and Smooth Muscle Function In 1934, Goldblatt and von Euler independently described the effects of seminal fluid on smooth muscle tone. Since the prostata, was held to be the source, von E uler (1935) introduced the term "prostaglandin" to classify this new group... G ...
5.)Moore-Olufemi, S.D., Olsen, A.B., Hook-Dufresne, D.M., Bandla, V. & Cox, C.S. (2015) Transforming Growth Factor-Beta 3 Alters Intestinal Smooth Muscle Function: Implications for Gastroschisis-Related Intestinal DysfunctionDig Dis Sci.60 ...
Minimally invasive saphenous vein harvesting: effects on endothelial and smooth muscle function Background. The long saphenous vein remains the commonest conduit used in coronary artery bypass grafting procedures. Surgical trauma during vein harvestin... Edward,A.,Black,... - 《Annals of Thoracic Su...
Myosin light chain kinase (MLCK) plays a central role in regulating the actin-myosin interaction of smooth muscle. MLCK phosphorylates the light chain of myosin in the presence of Ca2+ and calmodulin (CaM) thereby activating myosin so that it can interact with actin. Besides this kinase activity...
Thus, myosin can be viewed to serve as an “engine” for smooth muscle contraction whereas the actin cytoskeleton may function as a “transmission system” in smooth muscle (Tang, 2015; Wang, Cleary, Wang, Li, & Tang, 2014; Wang, Cleary, Wang, & Tang, 2013). In recent years, ...
observations will need to be investigated further. The beneficial effects provided by STO cells are important during the initial phase of the smooth muscle cell culture. It is likely that other cell types within ISMC Mix eventually take over the function of STO cells due to the mitomycin C ...
The turnover rate of muscle proteins was related to the physiological function of the muscle in dogs, fowl, rats, and mice. The turnover rates of mixed muscle proteins were most rapid in cardiac muscle, intermediate in red tonic and mixed fiber-type muscles, and slowest in white twitch skel...
In conclusion, in this cohort of African Americans visit-to-visit and 24-h BP variability were associated with measures of endothelial injury, endothelial function and smooth muscle function. These results suggest that BP variability may influence the pathogenesis of CV disease, in part, through ...
We confirmed that Deg-AZM can function strongly on intestinal peristalsis and identified transgelin as its potential molecular target. Furthermore, our pharmacological studies showed that the binding of Deg-AZM to transgelin enhanced the contractility of intestinal smooth muscle cells by facilitating the ...