thus increasing the rate of detoxification. This, in turn, increases the tolerance of the drug, meaning that higher doses are required to achieve a particular effect such as sedation. Also, because some of these detoxification enzymes present in smooth endoplasmic reticulum have broad actions, the...
meaning this moth inadvertently brought a friend, too. Both specimens were found, which amazed researchers who already knew clearwings to be notoriously difficult to find. Yet Daisy's mother somehow
(Diana.Klein@uk- essen.de) Hox genes are involved in vascular wall-resident multipotent stem cell differentiation into smooth muscle cells Diana Klein1, Mohamed Benchellal1, Veronika Kleff2, Heinz Gu¨nther Jakob3 & Su¨leyman Ergu¨n4 1Institute of Cell Biology (Cancer Research), University...
Serum amyloid A (SAA) is an uremic toxin and acute phase protein. It accumulates under inflammatory conditions associated with high cardiovascular morbidity and mortality in patients with sepsis or end-stage renal disease (ESRD). SAA is an apolipoprotein of the high-density lipoprotein (HDL). SAA...
The airways are hyper-responsive in asthma meaning that they are more likely to narrow in response to a bronchoconstricting stimuli than in health. In addition, the ASM is hyper-contractile in asthma and is a key contributor to this AHR [[6], [7], [8]]. The ASM is also infiltrated ...
We next questioned the biological meaning of the reduction in the miR-27a-3p level in vascular calcification. To do this, we first checked whether miR-27a-3p affects calcification in A10 cells. When control miRNA was transfected, treatment with Pi for 6 days induced an 8-fold increase in th...
As head of the division “Biophysics of Macromolecules,” Jörg has published—inter alia—a series of major contributions in the field of biophysics and molecular biology of cytoskeletal proteins. Comment As already mentioned in the first article of this series on cell differentiation processes in...
According to the circRNA microarray, we found that circNRG-1 was also down-regulated by Ang II, and this circRNA was not on the list of circBase, meaning that circNRG-1 is a new circRNA, so we used RT-PCR and Sanger sequencing to confirm whether circNRG-1 was derived from NRG-1 ...
In patients with chronic kidney disease (CKD), an endoplasmic reticulum (ER) stress-mediated phenotypic switch in vascular smooth muscle cells (VSMCs) is critical for vascular calcification (VC). Terpinen-4-ol hinders posttranslational PERK formation at the K889 acetylation site by increasing SIRT...
Quantitative real-time RT-PCR was performed in a Rotor-Gene Q (Qiagen, Hilden, Germany) using the 5x QPCR Mix EvaGreen (No Rox) (BS76.590.5000, Bio&SELL GmbH, Feucht, Germany) and water for Molecular Biology (Cat. no. H20MB0106, Merck Millipore, Darmstadt, Germany). PCR was ...