Conversely, autophagy modulators can alter SMN protein levels. Treating cultured motor neurons isolated from wild-type mice with mTORC1 inhibitor rapamycin, which is believed to enhance the activity of autophagy [172,173], showed increased SMN levels, whilst in BafA1-treated motor neurons SMN levels...
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在某些实施方式中,核苷的糖环可以在任意位置被修饰。可以在本发明中使用的糖修饰的例子包括,但不限于,含有选自下述糖取代基团的化合物:oh、f、o-烷基、s-烷基、n-烷基或o-烷基-o-烷基,其中的烷基、烯基和炔基可以是取代或非取代的c1至c 10 烷基或c2至c 10 烯基和炔基。在某些此类实施方式中,此类取代...
(rm)-炔基、o-亚烷基-o-烷基、炔基、烷芳基、芳烷基、o-烷芳基、o-芳烷基、o(ch2)2sch3、o(ch2)2on(rm)(rn)或och2c(=o)-n(rm)(rn),其中每个rm和rn独立地为h、氨基保护基或取代或未取代的c1-c10烷基,以及cook等人,u.s.6,531,584;cook等人,u.s.5,859,221;和cook等人,u.s.6,005,087...
nge nach EN 5581,Serie 49Zum Einbau zwischen Flansche nach DIN PN 40DN 40 北京汉达森专业销售比利时Sodeco"Powersem si PSDH175/16 Powersem 北京汉达森专业销售德国Powersem"Elektromotorenwerk EDS 71K 4-C1EB (unsere ID-Nr.: T9588)230 V, 50 Hz, 0,37 kW, 1400 U/min, B14(105), IP54, WKL F...
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