Smc–ScpABarchaeacondensinkite proteinsSMC complexes play a central role in chromosome organization in all domains of life. The bacterial Smc鈥揝cpAB complex is a three-subunit complex composed of Smc, ScpA and ScpB. ScpA bridges the two ATPase domains of the Smc homodimer, while ScpB, ...
在电子工程领域,SMC(Surface Mount Component,表面贴装元件)和MCU(Microcontroller Unit,微控制器)是两个截然不同的概念。它们分别代表了不同的技术层面和应用场景。以下是对两者的详细比较: 一、定义及基本属性 SMC(Surface Mount Component) 定义:SMC是指采用表面贴装技术的电子元器件。这些元件通过焊接直接固定在电...
ScpA connects the two ATPase heads of the Smc homodimer. (ii) The Smc1/3 cohesin complex. (iii) The Smc5/6 complex. (iv) The condensin I complex. H, D2, and G stand for CAP-H, CAP-D2, and CAP-G, respectively. (v) The condensin II complex. H2, D3, and G2 stand for...
Preincubation of SMC with four- and eightfold molar excesses of ScpA and ScpB, respectively, reduced the average number of clusters on DNA (0.5±0.7 with ScpAB, 2.8±1.5 without ScpAB; mean±s.d.; Fig. 2d). This difference was further supported by bootstrapping analyses that showed that...
The kleisin protein ScpA connects the head domain of one Smc subunit to the head-proximal arm (“neck”) of the other, together forming a ring-shaped protein complex capable of entrapping chromosomal DNA (Bürmann et al., 2013; Gligoris et al., 2014; Wilhelm et al., 2015). Two ScpB...
Several independent experimental approaches revealed interactions of the SMC proteins with synaptonemal complex-specific proteins SCP2 and SCP3. These results suggest a model for the arrangement of SMC proteins in mammalian meiotic chromatin. CAS-2 JCR-Q2 SCIE 141 被引用 · 0 笔记 引用 Mammalian ...
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Most other bacteria rely on a related condensin, composed of an SMC homodimer and the two non-SMC subunits ScpA and ScpB [7,11,17,18]. In this review, this complex is referred to as SMC–ScpAB. View article Mitosis James R. Paulson, ... William C. Earnshaw, in Seminars in Cell...
ScpB also contains two winged-helix motifs and dimerizes through its C-terminal half (26). It has been reported that ScpB interacts with the head domain of SMC in the presence of ScpA (20). The precise manner in which the SMC complex can tether and condense DNA molecules and the role...