Potential virulence determinants in terminal regions of variola smallpox virus genome. Nature 366:748-751.Massung R F, Esposito J J, Liu L Q, Utterback T R, Knight J C, Aubin L, Yuran T E, Parsons J M, Loparev V N, Selivanov N A, Cavallaro K F, Kerlavage A R, Mahy B W,...
Smallpox Virus Overview:Smallpoxis a highly contagious infection caused by the enveloped, doubled-stranded DNA virus smallpox, also known as variola virus (Figure 1). The virus ranges in size from 200 nm (nanometres) to 400 nm and possesses a genome that is 200 kilobase pairs long, maki...
Among these, the genus Orthopoxvirus, which includes Variola virus, Cowpox virus, Monkeypox virus, and Vaccinia virus, holds the greatest importance to human health (Table 1). Variola virus, the causative agent of smallpox, is alone among the orthopoxviruses as a pathogen solely of humans....
Among these, the genus Orthopoxvirus, which includes Variola virus, Cowpox virus, Monkeypox virus, and Vaccinia virus, holds the greatest importance to human health (Table 1). Variola virus, the causative agent of smallpox, is alone among the orthopoxviruses as a pathogen solely of humans....
Smallpox is a deadly and debilitating disease that killed hundreds of millions of people in the past century alone. The use of Vaccinia virus-based smallpox vaccines led to the eradication of smallpox. These vaccines are remarkably effective, inducing the characteristic pustule or “take” at the...
Deadline set for United States and the Soviet Union to destroy the virus; Preservation of the virus at the Centers for Disease Control and at the Research Institute for Viral Preparations; Study on the virus genome by a technical committee....
Potential virulence determinants in terminal regions of variola smallpox virus genome SMALLPOX eradication culminated the most successful antimicrobial campaign in medical history. To characterize further the linear double-stranded DNA genom... RF Massung,JJ Esposito,LI Liu,... - 《Nature》 被引量:...
Mayer H, Sutter G, Mayr A. Mapping of deletions in the genome of highly attenuated vaccinia virus MVA and their influence on virulence. J Gen Virol. 1991; 72: 1031-1038. Greenberg RN, Overton ET, Haas DW, Frank I, Goldman M, von Krempelhuber A, et al. Safety, immunogenicity and sur...
de-novo-synthesis (re-building the virus based on the known and published genome – sequence is available on the internet). The classification of the smallpox virus as a re-emerging threat in terms of a BW agent is due to several co-founding factors: ...
evolution of the poxvirus. Recently, small fragments of the poxvirus genome were detected. With the genetic information obtained, a new phylogeny ofsmallpox viruswas described. The interest in conducting studies on ancient strains is discussed, in order to explore the natural history of this ...