Vaccinationmay prevent or lessen the disease or limit its spread. However, this is also associated with life-threatening reactions (estimated to be 15 per million first-time vaccinations). Antiviral agents are also available, although these are not proven to reduce mortality and are associated with...
Smallpox reached its peak in the crowded cities of 18th century Europe, taking 400,000 lives per year and killing five reigning European monarchs ( 2,3 ). During this period, 10% of Swedish infants died of smallpox each year, and 10% of all deaths in London were attributable to the ...
anannualglobal expenditure of about US$1000 million for vaccination, airport inspections, etc., made necessary by the existence of smallpox. This equation takes no account of the deaths, misery, and costs of smallpox in afflicted people, or of the medical complications of untoward reactions to ...
smallpox,acute, highly contagious disease causing a high fever and successive stages of severe skin eruptions. Occurring worldwide in epidemics, it killed up to 40% of those who contracted it and accounted for more deaths over time than any other infectious disease. Spreading to the New World ...
“A report on vaccine-related deaths in the United States during the 1960s found that 12 of the 68 deaths occurred in unvaccinated persons exposed to recently vaccinated family members or friends, a finding that demonstrates the potential gravity of the problem.” ...
Exact numbers of deaths are not recorded but estimates amount to 400 million people in the 20th century alone [1]. The origin of VARV remains unknown; the first clinical descriptions of smallpox were noted in China (4th century), in India (7th century), and in the Mediterranean area (...
The epidemic infected 175 people, causing 35 deaths. Authorities declared martial law, enforced quarantine, and undertook widespread re-vaccination of the population, enlisting the help of the WHO. In two months, the outbreak was over.[135] Prior to this, there had been a smallpox outbreak in...
In the year following the total deaths were 338,979, of which the registered deaths from old age were 35,063, and the deaths from violence 11,980. The proportion of deaths for the whole population was 21 per thousand. The annual slaughter in England and Wales from preventable causes of ...
As in previous years, tho type of the disease in the United States was mild, and it is prob- able that not more than ten deaths occurred. There is good reason to believe that the present decline is real, and that the disease will be eradicated in tho next decade. During tho past ...
At one time it may have accounted for 10% of all deaths in the world (3). Smallpox is caused by the variola virus, which enters via the respiratory tract to infect local lymph nodes. The clinical course of smallpox has been recently well described by Breman and Henderson (4). In ...