PCO371 is expected to provide three advantages: robust serum Ca control, low risk of hypercalciuria and a decrease in pill burden. However, we should bear in mind that rat skeleton is different from human skeleton, thus non-rodent animal models for studying human bone metabolism are needed to...
After cooling, an excess amount of ethanol–water mixture (10:1) was added and stirred, resulting in white precipitates. The product was isolated by suction filtration, and further purification was achieved by zone-temperature sublimation to afford white solid (44.7 g, 92%). 1H-NMR (400 MHz...