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we identify artepillin C (APC) from propolis as an inhibitor of CREB-CRTC2 interaction. Without apparent toxicity, APC protects mice from high fat diet-induced obesity, decreases fasting glucose levels, enhances insulin sensitivity and reduces lipid levels in the serum and liver by suppressing CRE...
These multi-subunit protein complexes use energy from ATP hydrolysis to disrupt or move nucleosomes, thereby remodeling chromatin and modulating access to DNA (Narlikar et al., 2013, Petty and Pillus, 2013, Hargreaves and Crabtree, 2011, Mahmoudi and Verrijzer, 2001). We have recently found ...
A SYSMEX XN-1000 V instrument (Kobe, Japan) was used to measure platelets (PLTs), white blood cells (WBCs), red blood cells (RBCs), and hemoglobin (HGB). Flow cytometric analysis of immune cells Flow cytometry was conducted using a Beckman Coulter counter (CytoFLEX, Brea, CA, USA) in...
intravenous, oral, parenteral, pulmonary, rectally via an enema or suppository, subcutaneous, subdermal, sublingual, transdermal, and transmucosal. In addition, administration can by means of capsule, drops, foams, gel, gum, injection, liquid, patch, pill, porous pouch, powder, tablet, or other ...
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