White matter lesions in cerebral small vessel disease are related to ischemic injury and increase the risk of stroke and cognitive decline. Pathological changes due to cerebral small vessel disease are increasi
1. Introduction Cerebral small vessel disease (SVD) manifests on conventional MR images (i.e. T1 and FLuid Attenuated Inversion Recovery (FLAIR)) as white matter hyperintensities (WMH) and lacunes of presumed vascu- lar origin (Wardlaw et al., 2013). These SVD markers...
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
deep grey and white matter, are supplied by perforating arteries with a specific regional distribution that contributes to a variable susceptibility to ischemia,3 and the occlusion of perforating arteries results in subcortical ischemic infarcts limited to the vascular distribution of the occluded vessel....
This review also acknowledges several limitations, primarily in its focus on discussing ischemic small vessel cognitive impairment related to LSAs. Additionally, the impact of related risk factors on cognitive impairment is mainly concentrated on the discussion of diabetes. Furthermore, detailed discussions...
Monogenic cerebral small-vessel diseases: diagnosis and therapy: consensus recommendations of the European Academy of Neurology. Eur J Neurol. 2020;27(6):909-927. doi:10.1111/ene.14183 PubMedGoogle ScholarCrossref 4. Joutel A, Corpechot C, Ducros A, et al. Notch3 ...
· Thomas Gattringer1,2 Received: 4 April 2024 / Revised: 13 May 2024 / Accepted: 17 May 2024 / Published online: 27 May 2024 © The Author(s) 2024 Abstract Background Recent small subcortical infarcts (RSSI) are the neuroimaging hallmark feature of small vessel disease (SVD)...
Methods Trial Design The SPRINT trial was designed to examine the effects of intensive SBP control vs standard SBP control on cardiovascular disease as the primary outcome and kidney function, dementia or decline in cognitive function, and small-vessel cerebral ischemic disease as secondary outcomes, ...
Changes of the retinal and choroidal vasculature in cerebral small vessel disease Article Open access 07 March 2022 Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases Article Open access 11 June 2020 References Pantoni L (2010) Cerebral small...
Rene´ IF de Coo6, Jan C den Hollander7, Renske Oegema1, Douglas B Gould4 and Grazia MS Mancini*,1 Familial porencephaly, leukoencephalopathy and small-vessel disease belong to the spectrum of disorders ascribed to dominant mutations in the gene encoding for type IV collagen alpha-1 (COL...