Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms are often highly inconsistent in nature and severity...
The continued increase in global life expectancy predicts a rising prevalence of age-related cerebral small vessel diseases (CSVD), which requires a better understanding of the underlying molecular mechanisms. In recent years, the concept of “inflammaging” has attracted increasing attention. It refers...
Small Vessel Cerebrovascular Pathology Identified by Magnetic Resonance Imaging Is Prevalent in Alzheimer's Disease and Mild Cognitive Impairment: A Potent... magnetic resonance imagingneuropsychological testingsmall vessel pathologyThere is evidence that Alzheimer's disease (AD) has significant cerebrovascular...
Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects with SVD...
The continued increase in global life expectancy predicts a rising prevalence of age-related cerebral small vessel diseases (CSVD), which requires a better understanding of the underlying molecular mechanisms. In recent years, the concept of “inflammagi
With the increase in life expectancy, age-related diseases are anticipated to cause an enormous burden on health care and social systems. Cerebral small vessel disease (cSVD) contributes to cognitive impairment and dementia in the elderly, with characteristic early deficits in information processing and...
Cerebral small vessel disease (CSVD) is nowadays recognized as one of the most important causes of vascular dementia: immunosenescence and inflammatory response, with involvement of the brain’s vascular system, constitute the basis of this disease [1]. The definition of CSVD refers to all the ...
cerebral small vessel disease; inflammatory markers; neutrophil count; neutrophil–lymphocyte ratio; white matter hyperintensities; lacunar infarcts; cerebral microbleeds 1. Introduction Small Vessel Disease (SVD), a prevalent condition in the aging brain, poses a substantial risk factor for cognitive ...
heavy metals; small vessel diseases; oxidative stress; endothelial dysfunction; ROS Graphical Abstract 1. Introduction Life expectancy is currently higher than at any other time in history, and is anticipated to rise persistently in industrialized countries. Consequently, age-associated morbidities will ...