Small vessel disease (SVD) is a pathology that affects microcirculation in the brain and can be detected by imaging techniques such as magnetic resonance and computed tomography. SVD leaves a heterogeneous phenotype of imaging markers, ranging from white matter changes to microbleeds. The pathogenesis...
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Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-brain barrier (BBB) leakage may be important in SVD-induced brain... JM Wardlaw,...
Can small-vessel disease-related cerebral abnormalities be used as a surrogate marker for vascular dementia trials? J Neural Transm Suppl 2002; 62: 61-67.↵ Fazekas F, Ropele S, Schmidt R. Can small-vessel disease-related cerebral abnormalities be used as a surrogate marker for vascular ...
This study investigates associations of genetically defined vascular traits with all-cause dementia and Alzheimer disease, while accounting for potential
Cerebral small vessel diseases (CSVD) is a forerunner of cognitive decline, vascular dementia, Alzheimer's disease, and stroke. Which BP index is closest associated with CVSD remains unclear. We aimed this study to examine the association of BP levels, measured by the office and ambulatory BP ...
Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke. 2005;36: 2116 -2120.van der Flier WM, van Straaten ECWA, Barkhof F. Small vessel disease and general cognitive function in non... P Box - 《Digest of the World Core Medical Journals》 被...
Objective: Alzheimer's disease and vascular dementia are responsible for more than 80% of dementia cases. These two conditions share common risk factors including hypertension. Cerebral small vessel disease (CSVD) is strongly associated with both hypertension and cognitive impairment. In this review, ...
Cerebral small vessel disease (SVD) encompasses progressive fibrosis/hyalinosis of the small arteries (lipohyalinosis) and arterioles (arteriolosclerosis) of the white matter (WM) resulting in ischemic WM damage. SVD is commonly assessed using a broad semi﹒uantitative (SQ) criterion. We ...
Objective: We examined the relationship between cerebral small vessel disease and motoric cognitive risk syndrome (MCR), a recently described pre-dementia syndrome, in Indian seniors. Methods: 139 participants (mean age 66.6 +/- 5.4 y, 33.1% female) participating in the Kerala-Einstein study in...