Global small vessel disease brain changes predict cognitive declinedoi:10.1038/s41582-019-0296-8Ian FyfeNature Reviews Neurology
To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy.Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 patients ...
Current research strategies are targeting elucidation of the mechanisms of small vessel disease pathogenesis and pursuing clinical trials of therapeutic agents to reduce the clinical manifestations of cerebral small vessel disease. Summary: Cerebral small vessel disease is common in aging adults and ...
et al. Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70, 935–942 (2008). Article PubMed CAS Google Scholar Smith, E. E. et al. Early cerebral small vessel disease and brain volume, cognition, and gait. Ann. Neurol. 77, ...
Structural changes in the lobar regions of brain in cerebral small-vessel disease patients with and without cognitive impairment: An MRI-based study with automated brain volumetryBrainAtrophyStructural covarianceCerebral small-vessel diseaseMagnetic resonance imaging...
Brain endothelial cells have unique properties in terms of barrier function, local molecular signaling, regulation of local cerebral blood flow (CBF) and i... AH Hainsworth,AT Oommen,LR Bridges - 《Brain Pathology》 被引量: 30发表: 2015年 Cerebral Small Vessel Disease and Arterial Stiffness: Ts...
It is unknown whether changes in cerebral small vessel disease (SVD) are limited to the brain or part of a generalized vascular disorder.We examined the sublingual microcirculation of 10 healthy controls, 10 patients with large vessel disease, and 8 with SVD, with side-stream dark field imaging...
Cerebral small vessel disease (CSVD) is strongly associated with both hypertension and cognitive impairment. In this review, we identify the pathophysiological changes in CSVD that are caused by hypertension and further explore the relationship between CSVD and cognitive impairment.Data Sources: We ...
small vessel disease Acronyms Any of multiple small cerebral infarcts in the corona radiata, internal capsule, striatum, thalamus, basis pontis, and/or cerebellum, occasionally preceded by transient symptoms, due to occlusion or stenosis of small penetrating branches of the middle and posterior cerebral...
We have tested whether small intraischemic variations in brain temperature influence the outcome of transient ischemia. To measure brain temperature, a thermocouple probe was placed stereotaxically into the left dorsolateral striatum of rats prior to 20 min of four-vessel occlusion. Rectal temperature ...