Clinical manifestations of SVD range from cognitive impairment to definite dementia, and other neurological symptoms may also occur. Both ischemic and hemorrhagic stroke may occur at every stage of the pathology.doi:10.1016/B978-0-12-815854-8.00003-3Francesco Arba...
38,39,40,41,42,43Fortunately, advancements in metabolomics technologies hold promise as non-invasive and high-throughput tool that conventionally divided into untargeted and untargeted analysis has demonstrated high value in investigation of metabolite signatures...
Centers for Disease Control and Prevention. Monkeypox signs and symptoms. Accessed July 5, 2022. https://www.cdc.gov/poxvirus/monkeypox/index.html 48. US Food and Drug Administration. FDA approves drug to treat smallpox. Accessed June 30, 2022. https://www.fda.gov/drugs/news-events-human...
The current treatment has been demonstrated to relieve symptoms, and the discovery of new small-molecule compounds has been regarded as a promising strategy. Of note, the homeostasis of the autolysosome pathway (ALP) is closely associated with PD, and impaired autophagy may cause the death of ...
Although observational studies have reported a positive association between depression and ischemic stroke, causality remains inconclusive. We aimed to assess the causal relationship of major depressive disorder (MDD) with ischemic stroke, especially with the small vessel stroke (SVS) subtype. ...
the body can’t produce enough insulin or can’t properly use the insulin it does have. Insulin is a hormone that helps regulate blood sugar levels. When blood sugar levels are too high, it can lead to serious health complications, including heart disease, stroke, kidney disease, and ...
Cardiovascular diseases and thromobosis are the leading causes of death worldwide1. Thrombus-induced myo- cardial infarction or ischemic stroke is the main cause of cardiovascular diseases (CVD)-related death. Thrombus formation is a crucial event in the pathophysiology of atherosclerotic cardiovascular...
Cerebrovascular disease is a major burden to individuals and their communities worldwide. Stroke is one of the leading causes of death and disability, and the prevention and treatment of stroke can be improved with a better understanding of its causation. Cerebral small vessel disease (SVD) is a...
Functional impact of the haplotype was determined by molecular genetic methods including real-time PCR, exon trapping, promoter deletion constructs and electrophoretic mobility shift assays. Symptomatic -10T allele carriers suffered from stroke, TIA, WML, and SFN with neuropathic pain. Patients’ mean ...
When small vessel ischemic disease results in stroke (a stroke is an emergency that requires prompt treatment to stop disease progression and increase chances of reversing the condition), symptoms presented include: Sudden confusion Numbness and weakness especially observed on one side of the body. ...