rho GTP-Binding Proteinscdc42 GTP-Binding Proteinrac GTP-Binding ProteinsCell ShapeUbiquitinationCell MovementSumoylationMesenchymal Stromal CellsRho GTPases are a class of evolutionarily conserved proteins comprising 20 members, which are predominantly known for their role in regulating the actin ...
Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (1996) The Ras GTPase-activating-protein-realted human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol 16:4869–4878 PubMed...
Rho family proteins and Ras transformation: the RHOad less traveled gets congested. The Rho family of small GTPases has attracted considerable research interest over the past 5 years. During this time, we have witnessed a remarkable increa... IM Zohn,SL Campbell,R Khosravi-Far,... - 《Onco...
Rho Family Small GTPases 来自 Springer 喜欢 0 阅读量: 105 作者: SB Heidelberg 摘要: The RHO genes code for a family of related proteins that can bind to and hydrolyze GTP. These proteins are similar to the Ras oncogenes and include RhoA, Rac1 and Cdc42. In the GTP‐bound state,...
Rho GTPases Related Targets Heterotrimeric G-protein GTPases Other Small Monomeric GTPases Like Gαproteins, small GTPases alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP) and so function as binary switches that regulate cytosolic signaling pathways. GDP/GT...
1.3. Structure and function of Rho family members The Rho GTPase family consists of 22 members. Rho GTPases have been implicated in many cellular processes, such as cell dynamics, cell growth, membrane trafficking, gene transcription, apoptosis, and cytokinesis. Cdc42, Rac, and RhoA are the ...
The Rho family of small GTPases, whose prototypes are RhoA, Rac1, and Cdc42, regulate many biologic processes, including cell polarization and morphogenesis. The exocyst is a conserved eight-subunit protein complex involved in the biogenesis of polarity; in yeast, it is a downstream effector ...
Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma rhotekintax-interacting protein-1Rho GTPasesPDZ domains represent one group of the major structural units that mediate protein interactions in intercellular ... ...
Regulation of Dendritic Spine Morphology by the Rho Family of Small GTPases: Antagonistic Roles of Rac and Rho 2000. Regulation of dendri- tic spine morphology by the rho family of small GTPases: Antagonistic roles of Rac and Rho. Cereb Cortex 10:927-938... A Tashiro,A Minden,R Yuste...
Small GTPases of the Rho family are potent modulators of the actin and microtubule cytoskeleton. Recent data indicate that the Ras-like RAP1 protein and various Rho proteins crosstalk to polarity proteins to induce spatially restricted cytoskeletal remodelling. This is required for cell polarization ...