Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset and poor efficacy of traditional therapies against metastatic PCa make this disease a heavy burden in global men’s health. Prostate c
Patients suffering SCC of the prostate presenting with CS usually present symptoms such as hypertension, hyperglycemia, alkalosis or hypokalemia; cushingoid phenotype is less frequent. Cortisol and ACTH levels are often high. Prostatic-specific antigen levels are usually normal. CT scan is the ...
However, PSA is not prostate cancer specific and can be found with normal prostate at equal or higher levels than in PCa. The non-specificity of PSA was particularly reported for Middle-Eastern and North African populations [7]. The poor specificity of serum PSA, the only current biomarker ...
with metastatic cells.3)miR-34c-5p and mi R-181b-2-3p were significantly different in urine and tissue sEVs between control subjects and high-risk PCa patients,and their expression levels were significantly decreased in metastatic PCa cells compared with normal prostate epithelial cells.Conclusion:...
Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients. Cancer Lett. 2017;403:318–329. doi: 10.1016/j.canlet.2017.06.036. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
et al. A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/ml at initial biopsy. Eur. Urol. 74, 731–738 (2018). CAS PubMed Google Scholar Mc...
with sEVs carrying GALA, mouse bone marrow-derived DCs have shown enhanced capacity for antigen presentation [182]. In another study, TDsEVs were encoded with two tumour antigens, prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), which increased the frequency of PAP-specific...
noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeut...
LUAD patients with low cfDNA Ratio have prolonged PFS and improved ORR, compared to those with high cfDNA Ratio. When stratified by therapy regimen, the predictive value of cfDNA Ratio is significant in patients with chemotherapy plus VEGFIs, while more patients need be included to validate the...
Prostate cancer with marked neuroendocrine (NE) differentiation belongs to the hormone resistant carcinomas. We report the development of TSH-secreting small cell prostate cancer (SCPC) from high grade adenocarcinoma (Gleason score 8) with an elevated number of chromogranin A positive cells located in...