effective therapeutics against COVID-19 are in high demand. Along with our improved understanding of the structure, function, and pathogenic process of SARS-CoV-2, many small molecules with potential anti-COVID-19 effects have been developed. So far, several...
Until now, effective therapeutics against COVID-19 are in high demand. Along with our improved understanding of the structure, function, and pathogenic process of SARS-CoV-2, many small molecules with potential anti-COVID-19 effects have been developed. So far, several antiviral strategies were ...
of fundamental advantage, for example in the treatment of cancer and different types of infectious diseases [41]. For this purpose, we have developed a new strategy for the multiple functionalisation ofCNTwith different types of molecules (Figure 4a) [42]. Afluorescent probefor trac...
ascertaining the potential of small molecule drugs to approach conserved proteins required for the viral replication of all coronaviruses, accelerated FDA approvals are anticipated for small molecules for the treatment of COVID19 shortly. Though the recent attempts invested in this direction in pursuit ...
The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation and replication cycle. Based on the conservation of 3CL protease substrate binding pockets a
These features, like the persistence of high viral fill (rating). variant (B.1.617.2) for over 29 times in six individuals with severe coronavirus disease (COVID\19) admitted towards the intensive treatment device (ICU) in Australia. One affected person (P6) remained tradition\positive 33...
Dengue fever is a virus spread by mosquitoes that has no effective treatment or vaccination. Several dengue cases combined with the current COVID-19 pandemic, exacerbates this problem. Two proteins, NS5 methyltransferase and NS2B/NS3 primary protease complexes, are crucial for dengue viral replicatio...
PKMYT1, protein kinase, membrane-associated tyrosine–threonine 1; STK26, serine–threonine kinase 26; Tchem, genes whose products can be targeted with small molecules better than the following bioactivity cutoff values: 30 nM for kinases, 100 nM for GPCRs and nuclear receptors, 10 μM for ...
Sirtuin 3 (SIRT3) belongs to the Sirtuin protein family, which consists of NAD+-dependent lysine deacylase, involved in the regulation of various cellular activities. Dysregulation of SIRT3 activity has been linked to several types of cancer, including b
These compounds are particularly useful in targeting MCL-1 and may be useful in the treatment of diseases as described herein. Thus, in certain aspects, the compounds of Formula A-L may exclude certain compounds of Table 1. The compounds of the invention may contain one or more asymmetric ...