Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan M. Douglas et al., "Small- molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan," Nature Communications, vol. 8, ...
p pBackground/p pThe ability to regulate metabolism is a fundamental process in living systems. We present an analysis of one of the mechanisms by which metabolic regulation occurs: enzyme inhibition and activation by small molecules. We look at the network properties of this regulatory system an...
we wondered whether this compound could provide metabolic benefits in vivo. Interestingly, we found that intraperitoneal injection (i.p.) of synthesized APC (10 or 20 mg/kg) reduced the body weights of both DIO anddb/dbmice (Fig.5aand Supplementary Fig.4a, b), which was mainly due ...
The germination process involves dynamic physiological, cellular and metabolic events that are controlled by the interplay of several gene products and different phytohormones. The small non-coding RNAs comprise key regulatory modules in the process of seed dormancy and germination. Recent studies have ...
metabolic disorders small-molecule inhibitors triacylglycerides ASJC Scopus subject areas Drug Discovery General Pharmacology, Toxicology and Pharmaceutics Molecular Medicine Biochemistry Pharmacology Organic Chemistry UN SDGs This output contributes to the following UNSustainable Development Goals (SDGs) ...
For these TKIs, the structural modified sites are active metabolic centers and CYP3A4 is identified as the primary metabolic enzyme. Considering the active intermediates, the crown ether ring of icotinib is oxidated to open to form an aldehyde; the indolylidene ring of famitinib is oxidated ...
journal of clinical endocrinology & metabolic disorders research article a small molecule induces oligodendrogenesis leading to myelin sheath repair 来自 dx.doi.org 喜欢 0 阅读量: 20 作者:N Sh,YJJ Clin,E Metabdisord,Jcmd-,SH Nye,JG Yarger ...
and the metabolic changes that occurred in microbes due to the response to treatment with the small molecule, carvacrol. 2. Results 2.1. Metabolomic Profiling of X. perforans, and Annotation In this study, 1477 and 1094 metabolites were identified in the positive and negative ion modes, ...