A 73-year-old man was admitted to our hospital complaining of general malaise, loss of appetite and body weight loss. Chest X-ray film showed left-sided pleural effusion. Computed tomographic (CT) scan of the chest also demonstrated left-sided pleural effusion with lung tumor and lymphnode ...
(range, 0.4 to 62.0 months), KEYTRUDA plus chemotherapy in the neoadjuvant setting followed by KEYTRUDA as monotherapy after surgical resection significantly improved overall survival (OS), reducing the risk of death ...
In the control group, there were five lymph nodes from the neck, armpits and groins, with an average size of 55.7 mm3, while only two lymph nodes from left groin were obtained in the M12 group, with the average size of 9.86 mm3 (P ¼ 0.0007, Figure 6E). In addition, bloody ...
Only two patients did not receive chemotherapy, one with stage T3N0 with one rib metastasis and one 82-old-man with a T2N2 tumor with a metastasis in the left major teres muscle. These two patients had a distant recurrence. TABLE 2. Treatment for Primary Tumor and Lymph Nodes (n = 39...
Central nervous system metastases at the time of diagnosis were found in 14% of the patients and pleural effusion in 50%. Finally, 86% of patients presented a functional performance status (ECOG) of 1. The haematologic characteristics of treatment-naive patients are www.bjcancer.com | DOI:...
Osimertinib is an effective treatment option for patients with advanced non-small cell lung cancer (NSCLC) with EGFR activation or T790M resistance mutations; however, acquired resistance to osimertinib can still develop. This study explored novel miRNA–mRNA regulatory mechanisms that contribute to ...
NSCLC IIIB with a pleural effusion or stage IV, EGFR expression by immunohistochemistry [≥ 1 positive tumor cell], age ≥ 18, ECOG PS 0–2, no known brain metastasis and no prior chemotherapy or anti-EGFR therapy) [35]. Data on the role of K-RAS mutations as predictive for benefit ...
(40%vs4%;P=0.001), which were more commonly reported among NSCLC patients. Approximately 84% of patients had adenocarcinoma and 90% presented stage IV disease. Central nervous system metastases at the time of diagnosis were found in 14% of the patients and pleural effusion in 50%. Finally,...
(MRC-5). Among them, the paired low-metastatic 95C and high metastatic 95D cell lines were subcloned from a low differentiated human large cell lung carcinoma cell line PLA-801. H1299 and H460 cell lines were derived from lymph node and pleural effusion metastatic sites, respectively. The...
For the enrichment of biological terms and functional groups, we used the two-sided (enrichment/depletion) test based on the hyper-geometric distribution. We set the statistical significance to 0.05 (p≤ 0.05), and we used the Benjamini–Hochberg adjustment to correct the p-value for the terms...