liver development. At birth, the pigs had a small proportion of human albumin-producing cells, the number of which was not clinically significant. In order to provide an advantage to the human hepatocytes,transgenic pigswere generated in which the pig hepatocytes expressed thethymidine kinasegene ...
Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal stem cells; however, it has been reported to c
in the right upper quadrant or epigastrium is suggestive of intussusception and is present in 25 to 60% of cases (Figure 52-2).39This is particularly true if the soft tissue mass exhibits the characteristic appearance of two concentric circles of soft tissue density representing the int...
Small dense low-density lipoprotein (sd-LDL) is an atherogenic lipoprotein closely associated with an increased risk of cardiovascular diseases. However, a precise analysis of the actual amount of sd-LDL-cholesterol (sd-LDL-C) in patients with metabolic syndrome (MS) has not been performed. Meth...
Learn about the veterinary topic of Infectious Diseases of the Liver in Small Animals. Find specific details on this topic and related topics from the Merck Vet Manual.
Several protocols have been proposed for the isolation of EVs. Conventional methods such as differential (ultra-)centrifugation, size exclusion chromatography, density gradient ultracentrifugation, ultrafiltration, precipitation- and affinity-based capturing methods remain the most common approaches in descending...
Besides already approved HDAC inhibitors and hypomethylating agents, histone lysine methylation represents an emerging therapeutic target in cancer5. However, posttranscriptional gene regulation frequently involves several levels of control, suggesting that the combination of drugs modulating different epigenetic...
A 46-yr-old multiparous cachetic woman presented with severe hypoalbuminemia in the absence of liver disease, proteinuria, and/or protracted starvation. The clinical presentation and work-up was indicative of protein-losing enteropathy. ... JD Henley,SS Kratzer,IS Seo,... - 《American Journal...
Lipid droplets which stained with oil-red-O in formalin-fixed frozen sections and showed uniform electron density under the electron microscope, characteristic of neutral lipid, were also observed in the epithelial cells and macrophages in the lamina propria of jejunum and duodenum and mesenteric lymph...
For example, in anastomosed tissue-engineered small intestinal cysts harvested at 20 weeks, the density and topographical distribution of immune cell subsets, namely T-cells, B-cells, and NK-cells, were found to be identical to those of normal jejunum (Perez et al., 2002). Furthermore, ...