Small cell tumours constitute a heterogeneous group of tumours that are difficult to distinguish from each other and for which there is no strict classification. In the setting of a tumour with a small cell phenotype in the thyroid, the first approach is to separate lymphomas from the other ...
The staining pattern of Myo-D1 is heterogeneous among E-RMS cells;358 nuclear labeling is most intense in small, primitive tumor cells, whereas larger cells with more obvious skeletal muscle differentiation generally are nonreactive.115 On occasion, Myo-D1 cross-reacts with unknown cytoplasmic ...
two multitarget c-Met inhibitors, crizotinib and cabozantinib, were approved for the treatment of NSCLC and medullary thyroid cancer (MTC) as well as RCC, respectively.49,
The panel recognizes that there are Two randomized trials that have evaluated the role of surgery in this population and that both did not but neither showed an overall survival benefit with the use of surgery.2,3 However, this population is heterogeneous and we the panel believes that these ...
School of Medicine, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy and 9Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA Prostatic carcinoma is a heterogeneous disease with frequent multifocality and variability in morphology. Pa...
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SAXS is also routinely applied to the analysis of heterogeneous mixture and oligomeric/aggregation assembly processes that are challenging to study using other structural techniques. It is a particularly powerful tool for the study of dynamic/flexible systems such as intrinsically disordered proteins and ...
The sonographic finding of a distinct thyroid nodule in the heterogeneous background of chronic lymphocytic thyroiditis led to the performance of a fine-needle aspiration biopsy and flow cytometry, with a high index of suspicion for thyroid lymphoma. Subsequent surgical removal of the thyroid gland, ...
Pulmonary non-small cell carcinoma (NSCC) is a heterogeneous group of disorders mainly comprised of adenocarcinomas (AC) and squamous cell carcinomas (SqCC). Distinction of these two entities is of importance for treatment selection as pemetrexed and bevacizumab are used in AC and not in SqCC1,...
Future research should aim to address these limitations by not only incorporating larger and more heterogeneous patient populations but also adopting a prospective design. Prospective studies would mitigate the inherent biases of retrospective data collection and allow for a more controlled and systematic ...