DNAplasmidspolyomavirusIn general, human pathogen-related small circular deoxyribonucleic acid (DNA) molecules are bacterial plasmids and a group of viral genomes. Plasmids are extra-chromosomal small circular DNAs that are capable of replicating independently of the host, and are present throughout a ...
The translation of mRNA molecules in these extracts were cooperatively... N Iizuka,L Najita,A Franzusoff,... - 《Molecular & Cellular Biology》 被引量: 481发表: 1994年 Centromeric DNA from Saccharomyces cerevisiae We have isolated 29 kilobase-pairs of DNA encompassing the centromere-linked ...
This article identifies the production of viral siRNAs templated by circular viral DNA reverse transcribed from viral RNAs. CAS PubMed PubMed Central Google Scholar Paulsen, T., Kumar, P., Koseoglu, M. M. & Dutta, A. Discoveries of extrachromosomal circles of DNA in normal and tumor cells...
. In bacteria, where base methylation is more common, some modifications have been shown to confer resistance to toxic antibiotics (reviewed inCundliffe, 1989) and even appear to be a factor in theheat shock response(Buglet al., 2000). Early occurring modifications also might fine-tune the ...
While different approaches have focused on regulation of CRISPR interference or editing in mammalian cells, none of the reported methods enable control of the nuclease activity in bacteria. Here, we develop RNA linkers to combine theophylline- and 3-methylxanthine (3MX)-binding aptamers with the ...
appear to predispose to tumor development.5The small intestine is thought to be relatively protected from tumors because of rapid cell turnover, general absence of bacteria, alkaline environment, increasedapoptosis, rapid transit time, a well-developed immunoglobulin A (IgA)–mediated immune system, ...
a In bold font, the molecules that are the focus of this review. b The most relevant industrial uses of silk and collagen and collagen-related materials. “Y” indicates use of the biomaterial in that industry Full size image As more applications are developed for spider silk [2], and ...
Protein–RNA interactions have crucial roles in various cellular activities, which, when dysregulated, can lead to a range of human diseases. The identification of small molecules that target the interaction between RNA-binding proteins (RBPs) and RNA is progressing rapidly and represents a novel st...
Some of the first examples of RNA targeting in an RNA-protein complex came from antibacterial small molecules targeting ribosomal RNA (rRNA). While these examples helped highlight the potential of RNA as a drug target, rRNA targeting has been recently reviewed and, therefore, is not discussed ...
molecules. MicroRNA-155, also known as miR-155, is a vital regulator in various cancer types. This miRNA has a carcinogenic role in a variety of gastrointestinal cancers, including pancreatic, colon, and gastric cancers. Since the abnormal production of miR-155 has been detected in various ...