Small cell lung carcinoma which constitutes 20% is in the extensive stage when diagnosed in 70% of patients. 5 years survival after lung cancer treatment remains low The high mortality rate is attributed to its early metastasis, particularly for non small cell lung carcinoma (NSCLC). Andrographis...
Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset and poor efficacy of traditional therapies against metastatic PCa make this disease a heavy burden in global men’s health. Prostate c
Small-cell lung cancer (SCLC) represents approximately 15% of lung cancer cases and has a poor prognosis; about two-thirds of patients present at an extensive-stage (ES) disease state, and the 5-year overall survival (OS) rate is limited to only 1–5% (refs.1,2). The addition of an...
Kirsten Rat Sarcoma viral oncogene homolog (KRAS) gene is a gene that produces a protein that functions in the cell signaling systems that regulate cell division, maturation, and growth. It is the most mutated oncogene in human cancers, which hinders the development of effective drugs against KRA...
activating downstream intracellular signaling cascades, which are closely related to cell proliferation, survival, and apoptosis.72Abnormal activation of EGFR mutations is an important contributor to the tumorigenesis of multiple cancer types, especially lung cancer, breast cancer, and pancreatic cancer.73,...
The small intestine epithelium is characterized by elongated domains towards lumen, called villi, composed of differentiated IEC and inward-invaginated domains called crypts, which contain ISC. From: Molecular Metabolism, 2022 About this pageAdd to MendeleySet alert ...
Small Cell Lung Cancer 4.95% Endometrial Carcinoma 3.48% Skin Cancer, Non-Melanoma 3.45% Bladder/Urinary Tract Cancer, NOS 2.78% RSPO3 Colorectal Cancer 0.90% Small Bowel Cancer ND Melanoma 1.84% Breast Cancer 0.48% Hepatocellular Carcinoma 0% Leukemia 0% Skin Cancer, Non-Melanoma 8.05% Thym...
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt pro...
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes were recently defined by neuroendocrine transcription factor (NETF) expressio
endometrial cancer small cell carcinoma survival outcome Introduction Small cell carcinomas can occur in almost any organ, although they are usually seen in the lung, and less frequently in the gastrointestinal and genitourinary tracts. In the female genital tract, the cervix is the most common site...