SCLC is further divided into two categories: oats-cell cancer [bronchial epithelial cells develop a hostile malignancy neuroendocrine (NE) tumor] and cSCLC (combined small-cell lung cancer and nonsmall cell lung cancer). 2.1.1 Oats-Cell Carcinoma When viewed under a microscope, these canc...
PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma Prabhu Thirusangu Upasana Ray Viji Shridhar Oncogene (2022) Cancer cell metabolic plasticity in migration and metastasis Jenna A. Mosier Samantha C. Schwager Cynthia A. Reinhart-King Clinical & Experimental...
club cells (2), PNECs (3), tuft cells (4), alveolar macrophages (5), AT1 pneumocytes (6), and AT2 pneumocytes (7). UponTP53andRB1loss, several cell types of the lung epithelium may transform into SCLC. Of note, lung epithelial cells may also result in lung adenocarcinoma due to dri...
Pathologic assessment and staging of multiple non-small cell lung carcinomas: a paradigm shift with the emerging role of molecular methods. Mod. Pathol. 37, 100453 (2024). Article PubMed Google Scholar Chang, J. C. et al. Comprehensive next-generation sequencing unambiguously distinguishes ...
Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation Am J Respir Crit Care Med., 197 (1) (2018), pp. 104-116 View in ScopusGoogle Scholar [17] Y. Nakao, T. Fukuda, Q. Zhang, T. Sanui, T. Shinjo, ...
NSCLC is the most common type of lung cancer, accounting for approximately 85% of the cases. The three most common forms of NSCLC are adenocarcinoma, squamous cell carcinoma as well as large cell carcinoma [7,8,9]. Common cancer treatment approaches include surgery, chemotherapy, and radiation...
The association between Lambert–Eaton myasthenic syndrome and small cell lung carcinomadoi:10.2147/itt.s31971Sarah EW Briggs, Paul Gozzard, Denis C TalbotDepartment of Oncology, Oxford University Hospitals Trust, Churchill Hospital, Oxford, UK Nuffield Department of Clinical Neurosciences, University of ...
Non-small cell lung cancer (NSCLC) is typically diagnosed at advanced stages, which limits the effectiveness of therapeutic interventions. The present study aimed to explore the role of the newly identified circLIFRSA in the PTEN/AKT signaling pathway an
cell proliferation, metastasis, and resistance to drugs [67]. In NSCLC, YAP1 is significantly upregulated and plays an oncogenic role compared to para-carcinoma normal tissues [189]. Huang et al. found that in lung squamous cell carcinoma cells, small-molecule digitoxin can downregulate YAP ...
Inhibition of PFKFB3 by the glycolytic inhibitor PFK158 and by shRNA stable knockdown in small cell lung carcinoma (SCLC) cell lines inhibited glycolysis, proliferation, spheroid formation, and the expression of cancer stem cell markers CD133, Aldh1, CD44, Sox2, and ABCG2. These factors are ...