small cell lung cancersurvivalBackground: Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear. Our aim was thus to investigate the organ specificity and timing of blood-borne metastases in a comprehensive...
2.1 Small-Cell Lung Cancer Small-cell lung cancer (SCLC) is an extremely hostile, undistinguishable tumor that starts from the forerunners of neuroendocrine cells. It is characterized via an excessive proliferation frequency and initial metastasis. Even though it can be very sensitive to cytot...
Figure 2. Phase II and III trials assessing an immune-chemotherapy strategy in the first-line setting in extensive-disease (ED) small cell lung cancer (SCLC) with outcomes. CI, confidence interval; CR, complete response; PR, partial response; CT, chemotherapy; HR, hazard ratio; OS, overall...
Small-cell lung cancer spreads quickly. From 67%-75% of people who develop small cell lung cancerwill have spread the SCLC outside of the lung to other parts of the body at the time of initial diagnosis. Small-cell lung cancer responds well to chemotherapy (using medications to kill cancer...
Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain poorly understood. Here, using intracranial injections in mice and assembloids be
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...
脑转移(Brain Metastasis,BM)是非小细胞肺癌(Non-Small Cell Lung Cancer,NSCLC)最常见的转移类型,通常与患者不良预后相关。患者一旦发生脑转移,可引起癫痫、语言问题、局部神经功能缺损、嗜睡、记忆问题和精神状态改变等中枢神经系统(Central Nervous System,CNS)并发症,如不及时治疗,病情可能快速进展,危及患者生命。
Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed lung cancers. Long non-coding RNAs (lncRNAs) can regulate gene expression and contribute to tumorigenesis through interactions with mic
2024年2月17日,香港中文大学(深圳)唐本忠院士,广西医科大学宁峙彭教授及广州医科大学张天富副教授共同通讯在Small(IF 13.3)在线发表了题为“Biomimetic nano-cancer stem cell scavenger for inhibition of breast cancer recurrence and metastasis after FLASH-radiotherapy” 的研究论文。该研究设计了一种肿瘤源性外泌...
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes were recently defined by neuroendocrine transcription factor (NETF) expressio