Symptoms of metastatic disease may include anorexia, bone pain, fatigue, headache, and seizures. Small cell lung cancer patients rarely survive more than a few months without treatment [3]. In patients without extensive tumor spread (limited disease) at the time of diagnosis, median overall...
Figure 4. Current challenges with the immune-chemotherapy strategy in extensive-disease small cell lung cancer (ED-SCLC). ICI, immune checkpoint inhibitors; PCI, prophylactic cranial irradiation; PS, performance status; METS, metastases, RT, radiotherapy. Limited efficacy of ICIs in SCLC There is ...
NSCLC is the most common type of lung cancer, accounting for approximately 85% of the cases. The three most common forms of NSCLC are adenocarcinoma, squamous cell carcinoma as well as large cell carcinoma [7,8,9]. Common cancer treatment approaches include surgery, chemotherapy, and radiation ...
Predictive biomarkers of ICI response in ES-SCLC. SCLC: small cell lung cancer; ES: extensive stage; PD-L1: programmed cell death 1 ligand 1; ICI: immune checkpoint inhibitor; TMB: tumor mutational burden; tTMB: tissue tumor mutational burden; bTMB: blood tumor mutational burden; TME: tumor ...
1. Non-Small Cell Lung Cancer Lung cancer is one of the most common malignances—annual morbidity and mortality rates are still rising, and patient is often diagnosed at advanced stage, that the reason for the poor progression as treatment options are limited. The International Agency for ...
Background: To date, in personalized medicine approaches, single-cell analyses such as circulating tumour cells (CTC) are able to reveal small structural cell modifications, and therefore can retrieve several biophysical cell properties, such as the cell
(autophagy enhancer-99), which activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms inDrosophilamodels of Parkinson’s and Huntington’s diseases. Furthermore, the ...
Abstract. Guillain-Barré syndrome (GBS) is defined as an acute, autoimmune polyradiculoneuropathy. It is a rare disease that occurs at a rate of 1.11
Circular RNA (circRNA) has been demonstrated to play a pivotal role in tumor development. This study aimed to investigate the regulatory mechanism of circMBOAT2 in non-small cell lung cancer (NSCLC) and its association with tumor growth induced by chroni
Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of patients present advanced disease at onset. However, in the last decade, multiple oncogenic driver alterations have been ...